2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

Base Information

• Chemical Name: 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone
• CAS No.: 1259322-21-8
• Molecular Formula: C₂₅H₂₅F₄N₅O₂S₂
• Molecular Weight: 567.631
• Mol file: 1259322-21-8.mol

Synonyms:2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

Chemical Property of 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

There total 6 articles about 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid (512809-60-8) + 4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidinium chloride (1259323-15-3) → 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone (1259322-21-8)

Guidance literature:

[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 0.5h;

4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidinium chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone (1259322-21-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / 1,2-dimethoxyethane / 75 °C / Inert atmosphere

1.2: 20 °C

2.1: sodium hydroxide; tetrabutylammomium bromide / toluene; water / 2 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.5 h

4.2: 2 h

With hydrogenchloride; N-chloro-succinimide; oxalyl dichloride; tetrabutylammomium bromide; N,N-dimethyl-formamide; sodium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; toluene;

Reference yield:

tert- butyl 4-(4-(hydroxymethyl)thiazol-2-yl)piperidine-1-carboxylate (864068-79-1) → 2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone (1259322-21-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 0.5 h

2.1: ethanol / 3 h / 20 °C

3.1: sodium hydroxide; tetrabutylammomium bromide / toluene; water / 2 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 0 - 20 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.5 h

5.2: 2 h

With 1H-imidazole; hydrogenchloride; oxalyl dichloride; tetrabutylammomium bromide; iodine; N,N-dimethyl-formamide; triphenylphosphine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;

upstream raw materials:

styrene

tert- butyl 4-(4-(hydroxymethyl)thiazol-2-yl)piperidine-1-carboxylate

[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

4-[4-({[5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]sulphanyl}methyl)-1,3-thiazol-2-yl]piperidinium chloride