2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid

Base Information

Chemical Name:2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid
CAS No.:1265323-31-6
Molecular Formula:C₂₈H₂₆F₃N₃O₄S
Molecular Weight:557.593
Hs Code.:

Synonyms:2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid

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Chemical Property of 2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid

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Technology Process of 2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid

There total 12 articles about 2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₄F₃N₃O₄SSi

: 1265323-31-6
2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; for 2h;

Reference yield:

: 208108-76-3
(4-phenyl-5-trifluoromethyl)thiophene-2-carboxylic acid

: 1265323-31-6
2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran

2.2: 60 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 2 h

With hydrogenchloride; oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 20099-89-2
4-Cyanophenacyl bromide

: 1265323-31-6
2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 96 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 1 h

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

4.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 75 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran

5.2: 60 °C

6.1: hydrogenchloride; water / tetrahydrofuran / 2 h

With hydrogenchloride; sodium tetrahydroborate; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; toluene;