ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-((Z)-N'-hydroxycarbamimidoyl)phenyl)ethyl)piperidin-3-yl)acetate

Base Information

• Chemical Name: ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-((Z)-N'-hydroxycarbamimidoyl)phenyl)ethyl)piperidin-3-yl)acetate
• CAS No.: 1265750-10-4
• Molecular Formula: C₂₄H₄₁N₃O₄Si
• Molecular Weight: 463.693
• Mol file: 1265750-10-4.mol

Synonyms:ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-((Z)-N'-hydroxycarbamimidoyl)phenyl)ethyl)piperidin-3-yl)acetate

Chemical Property of ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-((Z)-N'-hydroxycarbamimidoyl)phenyl)ethyl)piperidin-3-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-((Z)-N'-hydroxycarbamimidoyl)phenyl)ethyl)piperidin-3-yl)acetate

There total 10 articles about ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-((Z)-N'-hydroxycarbamimidoyl)phenyl)ethyl)piperidin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-cyanophenyl)ethyl)piperidin-3-yl)acetate (1265323-60-1) → ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-((Z)-N'-hydroxycarbamimidoyl)phenyl)ethyl)piperidin-3-yl)acetate (1265750-10-4)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In isopropyl alcohol; at 75 ℃;

Reference yield:

4-Cyanophenacyl bromide (20099-89-2) → ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-((Z)-N'-hydroxycarbamimidoyl)phenyl)ethyl)piperidin-3-yl)acetate (1265750-10-4)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / 96 h / 20 °C

2: sodium tetrahydroborate / methanol / 1 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

4: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 75 °C

With sodium tetrahydroborate; hydroxylamine hydrochloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; isopropyl alcohol; toluene;

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-((Z)-N'-hydroxycarbamimidoyl)phenyl)ethyl)piperidin-3-yl)acetate (1265750-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 75 °C

With hydroxylamine hydrochloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; isopropyl alcohol;

upstream raw materials:

4-Cyanophenacyl bromide

t-butyldimethylsiyl triflate

(S)-4-(2-bromo-1-hydroxyethyl)benzonitrile

(S)-(+)-2-(4-cyanophenyl)oxirane

Downstream raw materials:

2-((R)-1-((S)-2-hydroxy-2-(4-(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid

ethyl 2-((R)-1-((S)-2-(tert-butyldimethylsilyloxy)-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetate