8-{2-[((1R,2S)-1-amino-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid methyl ester hydrochloride

Base Information

Chemical Name:8-{2-[((1R,2S)-1-amino-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid methyl ester hydrochloride
CAS No.:1051391-40-2
Molecular Formula:C₂₂H₃₁N₃O₆S*ClH
Molecular Weight:502.032
Hs Code.:

Synonyms:8-{2-[((1R,2S)-1-amino-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid methyl ester hydrochloride

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Chemical Property of 8-{2-[((1R,2S)-1-amino-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid methyl ester hydrochloride

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Technology Process of 8-{2-[((1R,2S)-1-amino-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid methyl ester hydrochloride

There total 6 articles about 8-{2-[((1R,2S)-1-amino-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1051391-38-8
8-{2-[((1R,2S)-1-tert-butoxycarbonylamino-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid methyl ester

: 1051391-40-2
8-{2-[((1R,2S)-1-amino-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 15h;

Reference yield:

: 56555-02-3
methyl 9-chloro-9-oxononanoate

: 1051391-40-2
8-{2-[((1R,2S)-1-amino-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dmap / dichloromethane / 15 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C

With hydrogenchloride; triethylamine; dmap; In 1,4-dioxane; dichloromethane;

Reference yield:

: C₁₄H₁₉N₃O₃

: 1051391-40-2
8-{2-[((1R,2S)-1-amino-2-vinyl-cyclopropanecarbonyl)-sulfamoyl]-phenylcarbamoyl}-octanoic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.75 h / 20 °C

2: triethylamine / dmap / dichloromethane / 15 h / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C

With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dmap; In tetrahydrofuran; 1,4-dioxane; dichloromethane;