(4S,5R)-2,4-Diphenyl-4,5-dihydro-oxazole-5-carbothioic acid S-phenyl ester

Base Information

Chemical Name:(4S,5R)-2,4-Diphenyl-4,5-dihydro-oxazole-5-carbothioic acid S-phenyl ester
CAS No.:186596-02-1
Molecular Formula:C₂₂H₁₇NO₂S
Molecular Weight:359.448
Hs Code.:

Synonyms:(4S,5R)-2,4-Diphenyl-4,5-dihydro-oxazole-5-carbothioic acid S-phenyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5R)-2,4-Diphenyl-4,5-dihydro-oxazole-5-carbothioic acid S-phenyl ester

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Technology Process of (4S,5R)-2,4-Diphenyl-4,5-dihydro-oxazole-5-carbothioic acid S-phenyl ester

There total 3 articles about (4S,5R)-2,4-Diphenyl-4,5-dihydro-oxazole-5-carbothioic acid S-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181294-27-9
(2S,3S)-3-Benzoylamino-2-hydroxy-3-phenyl-thiopropionic acid S-phenyl ester

: 186596-02-1
(4S,5R)-2,4-Diphenyl-4,5-dihydro-oxazole-5-carbothioic acid S-phenyl ester

Guidance literature:: With thionyl chloride; Yield given. Multistep reaction; 1.) CHCl₃, 45 deg C, 4 h, 2.) 1,2-dichloroethane, reflux, 5 h;
DOI:10.1021/jo9703212

Reference yield:

: 144192-69-8
(tert-Butyl-dimethyl-silanyloxy)-thioacetic acid S-phenyl ester

: 186596-02-1
(4S,5R)-2,4-Diphenyl-4,5-dihydro-oxazole-5-carbothioic acid S-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) bis<((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)methyl>bromoborane, Et₃N, 2.) HCl, 3.) aq. HF / 1.) ether, CH₂Cl₂, -78 deg C, 0.5 h, 2.) MeOH, room temperature, 1 h, 3.) CH₃CN

2: 1.) SOCl₂ / 1.) CHCl₃, 45 deg C, 4 h, 2.) 1,2-dichloroethane, reflux, 5 h

With hydrogenchloride; thionyl chloride; hydrogen fluoride; triethylamine; bis<((1S,2S,5R)-2-isopropyl-5-methylcyclohexyl)methyl>bromoborane;
DOI:10.1021/jo9703212