methanesulfonic acid 3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-ynyl ester

Base Information

Chemical Name:methanesulfonic acid 3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-ynyl ester
CAS No.:476461-15-1
Molecular Formula:C₁₈H₂₄O₇S
Molecular Weight:384.45
Hs Code.:

Synonyms:methanesulfonic acid 3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-ynyl ester

Suppliers and Price of methanesulfonic acid 3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-ynyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methanesulfonic acid 3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methanesulfonic acid 3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-ynyl ester

There total 7 articles about methanesulfonic acid 3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 476461-14-0
3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-yn-1-ol

: 7143-01-3
Methanesulfonic anhydride

: 476461-15-1
methanesulfonic acid 3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-ynyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;
DOI:10.1021/ol0201557

Reference yield:

: 91312-68-4
methyl 3-O-(tert-butyldimethylsilyl)-2,4-dideoxy-6-oxo-α-D-erythro-hexopyranoside

: 476461-15-1
methanesulfonic acid 3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; zinc / CH₂Cl₂ / 22 °C

1.2: 63 percent / triphenylphosphine; zinc / CH₂Cl₂ / 22 °C

2.1: 88 percent / HF / acetonitrile; H₂O / 0.67 h / 0 °C

3.1: sodium hydride / tetrahydrofuran; various solvent(s) / 1.5 h / 0 °C

3.2: 94 percent / sodium iodide / tetrahydrofuran; various solvent(s) / 22.5 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: 80 percent / sodium iodide / tetrahydrofuran / 3 h / 0 °C

5.1: diisopropylethylamine / CH₂Cl₂ / 0 °C

With n-butyllithium; hydrogen fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; zinc; In tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;
DOI:10.1021/ol0201557

Reference yield:

: 91312-61-7
methyl 3-O-(tert-butyldimethylsilyl)-2,4-dideoxy-6-O-(triphenylmethyl)-α-D-erythro-hexapyranoside

: 476461-15-1
methanesulfonic acid 3-[6-(S)-methoxy-4-(R)-(4-methoxybenzyloxy)-tetrahydropyran-2-(S)-yl]-prop-2-ynyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: Na / diethyl ether; liquid ammonia / 0.83 h / -78 - 22 °C

1.2: 98 percent / ammonium chloride / diethyl ether / 12 h / 22 °C

2.1: 98 percent / DMSO; (COCl)2; ET₃N / CH₂Cl₂ / 2.33 h / -78 - 22 °C

3.1: triphenylphosphine; zinc / CH₂Cl₂ / 22 °C

3.2: 63 percent / triphenylphosphine; zinc / CH₂Cl₂ / 22 °C

4.1: 88 percent / HF / acetonitrile; H₂O / 0.67 h / 0 °C

5.1: sodium hydride / tetrahydrofuran; various solvent(s) / 1.5 h / 0 °C

5.2: 94 percent / sodium iodide / tetrahydrofuran; various solvent(s) / 22.5 h / 20 °C

6.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: 80 percent / sodium iodide / tetrahydrofuran / 3 h / 0 °C

7.1: diisopropylethylamine / CH₂Cl₂ / 0 °C

With n-butyllithium; oxalyl dichloride; hydrogen fluoride; sodium; sodium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; zinc; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; ammonia; water; acetonitrile; 2.1: Swern oxidation;
DOI:10.1021/ol0201557