4-(4-hydroxy-3-methoxyphenyl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione

Base Information

• Chemical Name: 4-(4-hydroxy-3-methoxyphenyl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione
• CAS No.: 1008428-14-5
• Molecular Formula: C₁₉H₁₈N₂O₂S
• Molecular Weight: 338.43

Synonyms:4-(4-hydroxy-3-methoxyphenyl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione

Chemical Property of 4-(4-hydroxy-3-methoxyphenyl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione

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Technology Process of 4-(4-hydroxy-3-methoxyphenyl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione

There total 1 articles about 4-(4-hydroxy-3-methoxyphenyl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

vanillin (121-33-5,8014-42-4) + thiourea (17356-08-0) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 4-(4-hydroxy-3-methoxyphenyl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione (1008428-14-5)

Guidance literature:

With poly(4-vinylpyridinium)hydrogen sulfate; In neat (no solvent); at 120 ℃;

DOI:10.1039/c4ra02514h

Reference yield: 88.0%

3-bromoacetylcoumarin (29310-88-1) + 4-(4-hydroxy-3-methoxyphenyl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione (1008428-14-5) → 3-(7-(4-hydroxy-3-methoxyphenyl)-6,7-dihydro-5H-benzo[h]-thiazolo[2,3-b]quinazolin-9-yl)-2H-chromen-2-one (1628798-81-1)

Guidance literature:

With acetic acid; for 1h; Reflux;

DOI:10.1039/c4ra02514h

Reference yield: 84.0%

4-(4-hydroxy-3-methoxyphenyl)-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione (1008428-14-5) + 4-chlorobenzoylmethyl bromide (536-38-9) → 4-(9-(4-chlorophenyl)-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]-quinazolin-7-yl)-2-methoxyphenol (1628798-70-8)

Guidance literature:

With acetic acid; for 3h; Reflux;

DOI:10.1039/c4ra02514h

upstream raw materials:

vanillin

thiourea

3,4-dihydronaphthalene-1(2H)-one

Downstream raw materials:

4-(9-(4-chlorophenyl)-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]-quinazolin-7-yl)-2-methoxyphenol

4-(9-(4-bromophenyl)-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]-quinazolin-7-yl)-2-methoxyphenol

3-(7-(4-hydroxy-3-methoxyphenyl)-6,7-dihydro-5H-benzo[h]-thiazolo[2,3-b]quinazolin-9-yl)-2H-chromen-2-one

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