3-{2-fluoro-3-aminobenzyl}-4-methyl-7-(5-fluoropyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Base Information

Chemical Name:3-{2-fluoro-3-aminobenzyl}-4-methyl-7-(5-fluoropyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran
CAS No.:946126-64-3
Molecular Formula:C₂₁H₁₅F₂N₃O₃
Molecular Weight:395.365
Hs Code.:

Synonyms:3-{2-fluoro-3-aminobenzyl}-4-methyl-7-(5-fluoropyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

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Chemical Property of 3-{2-fluoro-3-aminobenzyl}-4-methyl-7-(5-fluoropyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

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Technology Process of 3-{2-fluoro-3-aminobenzyl}-4-methyl-7-(5-fluoropyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

There total 10 articles about 3-{2-fluoro-3-aminobenzyl}-4-methyl-7-(5-fluoropyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 946126-97-2
2-oxo-2H-3-(2-fluoro-3-aminobenzyl)-4-methyl-7-hydroxy-1-benzopyran

: 62802-42-0
2-chloro-5-fluoropyrimidine

: 946126-64-3
3-{2-fluoro-3-aminobenzyl}-4-methyl-7-(5-fluoropyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:: 2-oxo-2H-3-(2-fluoro-3-aminobenzyl)-4-methyl-7-hydroxy-1-benzopyran; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

2-chloro-5-fluoropyrimidine; In N,N-dimethyl-formamide; at 100 ℃; for 5h;

Reference yield:

: 53553-14-3
2-chloro-3-nitrobenzoic acid methyl ester

: 946126-64-3
3-{2-fluoro-3-aminobenzyl}-4-methyl-7-(5-fluoropyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:: Multi-step reaction with 7 steps

1.1: cesium fluoride / dimethyl sulfoxide / 0.67 h / 140 °C

2.1: diisobutylaluminium hydride / toluene / 1 h / -78 - 0 °C

2.2: 1 h / -78 - 20 °C

3.1: phosphorus tribromide / diethyl ether / 0.5 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 20 °C

5.1: sulfuric acid / 0 - 20 °C

6.1: tin(II) chloride hydrate / ethyl acetate / 1 h / Inert atmosphere; Reflux

7.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

7.2: 5 h / 100 °C

With tin(II) chloride hydrate; sulfuric acid; phosphorus tribromide; sodium hydride; diisobutylaluminium hydride; cesium fluoride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 3970-40-9
2-chloro-3-nitrotoluene

: 946126-64-3
3-{2-fluoro-3-aminobenzyl}-4-methyl-7-(5-fluoropyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: cesium fluoride / dimethyl sulfoxide / 10 h / 140 °C / Inert atmosphere

2.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux; Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 20 °C

4.1: sulfuric acid / 0 - 20 °C

5.1: tin(II) chloride hydrate / ethyl acetate / 1 h / Inert atmosphere; Reflux

6.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

6.2: 5 h / 100 °C

With N-Bromosuccinimide; tin(II) chloride hydrate; sulfuric acid; sodium hydride; cesium fluoride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;