3970-40-9

Basic information

• Product Name: 2-CHLORO-3-NITROTOLUENE
• Synonyms: 2-CHLORO-3-NITROTOLUENE 98%;2-chloro-1-methyl-3-nitrobenzene;2-chloro-1-methyl-3-nitro-benzene;2-Cloro-3-nitrotoluene;2-CHLORO-3-NITROTOLU;2-Chloro-3-methylnitrobenzene, 2-Chloro-1-methyl-3-nitrobenzene;2-Chloro-3-nit;2-CHLORO-3-NITROTOLUENE
• CAS NO: 3970-40-9
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• EINECS: 223-591-9
• Product Categories: API intermediates;Chlorine Compounds;Nitro Compounds;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;Aromatic Hydrocarbons (substituted) & Derivatives
• Mol File: 3970-40-9.mol

Chemical Properties

• Melting Point: 21 °C(lit.)
• Boiling Point: 147 °C25 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.298 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.557(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-CHLORO-3-NITROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-NITROTOLUENE(3970-40-9)
• EPA Substance Registry System: 2-CHLORO-3-NITROTOLUENE(3970-40-9)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-50
• Safety Statements: 61
• RIDADR: UN 2433 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 3970-40-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Chloro-3-nitrotoluene is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Dye and Fluorescent Brightener Production:
2-CHLORO-3-NITROTOLUENE serves as an essential intermediate in the production of dyes and fluorescent brighteners, enhancing the color and brightness of various materials.
Used in Chemical Reagent Applications:
2-Chloro-3-nitrotoluene is employed as a chemical reagent in a range of industrial processes, facilitating chemical reactions and contributing to the synthesis of other organic compounds.
Used in Environmental Management:
As a potential environmental contaminant, 2-Chloro-3-nitrotoluene requires careful handling and disposal to prevent adverse effects on human health and the environment, highlighting its importance in environmental management and safety protocols.

InChI:InChI=1/C7H6ClNO2/c1-5-3-2-4-6(7(5)8)9(10)11/h2-4H,1H3

Upstream product

• 13073-29-5 2-methyl-6-nitrophenol 
• 95-48-7 ortho-cresol 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 
• 59907-22-1 N-(2-methyl-6-nitrophenyl)acetamide 
• 120-66-1 N-(2-methylphenyl)acetamide 
• 99-08-1 1-methyl-3-nitrobenzene 
• 7782-50-5 chlorine 
• 95-49-8 2-methylchlorobenzene 
• 7697-37-2 nitric acid 
• 570-24-1 2-Methyl-6-nitroaniline 

Downstream Products

• 80689-19-6 7-Methyl-3H-benzothiazol-2-one 
• 93566-50-8 3-<2-(2-methyl-6-nitrophenoxy)phenyl>prop-1-ene 
• 89642-16-0 α-bromo-2-chloro-3-nitrotoluene 
• 58755-57-0 2-chloro-3-nitrobenzaldehyde 
• 154078-75-8 2-methyl-6-nitrobenzenethiol 
• 92149-67-2 2,2'-Dinitro-6,6'-dimethyl-diphenylether 
• 29027-17-6 2-chloro-3-methylaniline 
• 3970-35-2 2-chloro-3-nitrobezoic acid 
• 356072-50-9 1-Benzyl-4-[(2-methyl-6-nitrophenyl)amino]piperidine 
• 910377-32-1 2-methyl-N-[2-(methylthio)ethyl]-6-nitroaniline 
• 70254-74-9 2,N-dimethyl-6-nitro-aniline 
• 946126-04-1 4-methyl-3-(2-fluoro-3-nitrobenzyl)-7-(pyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran 
• 946126-93-8 C₂₃H₁₈FN₃O₇S 
• 946127-78-2 2-(2-(2-fluoro-3-nitrobenzyl)-3-methylbenzo[b]thiophen-6-yloxy)pyrimidine 

Relevant articles and documents

Synthesis method of 2-fluoro-3-nitrobenzoic acid intermediate raw material

The invention discloses a synthesis method of a 2-fluoro-3-nitrobenzoic acid intermediate raw material. The invention provides a novel synthesis route, and an important medical intermediate can be rapidly and conveniently prepared from cheap and easily available raw materials. The process method comprises the following steps: starting from o-methylphenol, carrying out nitration reaction to selectively generate a key intermediate 2-methyl-6-nitrophenol, carrying out hydroxyl chlorination to generate 2-chloro-3-nitrotoluene, then carrying out fluorination reaction to generate 2-fluoro-3-nitrotoluene, and finally oxidizing methyl under the action of an oxidant to generate 2-fluoro-3-nitrobenzoic acid. The method is not only high in yield, but also suitable for large-scale production.

Nitration of deactivated aromatic compounds via mechanochemical reaction

A variety of deactivated arenes were nitrated to their corresponding nitro derivatives in excellent yields under high-speed ball milling condition using Fe(NO3)3·9H2O/P2O5 as nitrating reagent. A radical involved mechanism was proposed for this facial, eco-friendly, safe, and effective nitration reaction.

INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE

Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, methods for use as Bruton's tyrosine kinase and methods of production.

Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions

Versatile and practical Ag/Cu-mediated decarboxylative halogenation between readily available aryl carboxylic acids and abundant NaX (X = I, Br, Cl) has been achieved under aerobic conditions in moderate to good yields. The halodecarboxylation is shown to be an effective strategy for S-containing heteroaromatic carboxylic acid and benzoic acids with nitro, chloro and methoxyl substituents at the ortho position. A gram-scale reaction and a three-step procedure to synthesize iniparib have been performed to evaluate the practicality of this protocol. A preliminary mechanistic investigation indicates that Cu plays a vital role and a radical pathway is involved in the transformation.

Quinoline compound containing perfluoroalkyl substituent, as well as preparation method and application of quinoline compound

The invention disclose a quinoline compound containing a perfluoroalkyl substituent, as shown in a general formula A-1, wherein the details of the definition of R2, R3, R4, R5, R6 and I are seen in the description. The invention further discloses a preparation method and application of the quinoline compound containing the perfluoroalkyl substituent. The quinoline compound containing the perfluoroalkyl substituent provided by the invention is suitable for agriculture insecticide.

Silver-catalyzed decarboxylative halogenation of carboxylic acids

Decarboxylative halogenation of carboxylic acids catalyzed by silver carbonate is reported. ortho-Nitrobenzoic acids react with copper(II) chloride or bromide in DMF/DMSO at 130-140 °C leading to the corresponding aryl halides in moderate to good yields.

Process for the preparation of 2-chloro-4-nitro-alkylbenzene

In the preparation of 2-chloro-4-nitro-alkylbenzene by reaction of 4-nitro-alkylbenzene with elemental chlorine or chlorine-releasing compounds in the presence of a Friedel-Crafts catalyst in the liquid phase, particularly high selectivities in respect of the target compounds chlorinated exclusively in the 2-position are achieved if a dibenzo-condensed sulphur heterocycle of the formula STR1 having the meanings given in the description for R1 to R8, X and n, is used as co-catalyst.