1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

Base Information

Chemical Name:1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester
CAS No.:331282-15-6
Molecular Formula:C₂₈H₃₂N₄O₄
Molecular Weight:488.586
Hs Code.:

1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6<i>H</i>-imidazo[4,5-<i>d</i>][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

Synonyms:1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

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Chemical Property of 1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

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Technology Process of 1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

There total 9 articles about 1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33950-71-9
ethyl 1-hydroxy-2-naphthoate

: 331282-15-6
1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: H₂ / 20percent Pd(OH)2/C / methanol / 48 h / 760.05 Torr

2.1: Br₂; AcOH / 1 h

3.1: K₂CO₃ / dimethylsulfoxide / 2 h / 60 °C

4.1: Pd(PPh₃)4 / dimethylformamide / 3 h / 80 °C

5.1: 9-BBN / tetrahydrofuran / 16 h

5.2: 30percent aq. H₂O₂; 3 N aq. NaOH / tetrahydrofuran / 4 h / 5 °C

6.1: CBr₄; Ph₃P / CH₂Cl₂ / 0.5 h

7.1: NaH; NaI / dimethylformamide

8.1: NaBH₄ / CH₂Cl₂; ethanol

With sodium tetrahydroborate; 9-borabicyclo[3.3.1]nonane dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; hydrogen; bromine; sodium hydride; potassium carbonate; acetic acid; triphenylphosphine; sodium iodide; 20percent Pd(OH)2/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm000355t

Reference yield:

: 331282-27-0
1-benzyloxy-4-[2-(8-oxo-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

: 331282-15-6
1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

Guidance literature:: With sodium tetrahydroborate; In ethanol; dichloromethane;
DOI:10.1021/jm000355t

Reference yield:

: 72079-77-7
6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one

: 331282-15-6
1-benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaH; NaI / dimethylformamide

2: NaBH₄ / CH₂Cl₂; ethanol

With sodium tetrahydroborate; sodium hydride; sodium iodide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000355t