(1R,2R)-1-(benzo[d][1,3]dioxol-5-yl)-3-(dimethyl(phenyl)silyl)-2-methylbut-3-en-1-ol

Base Information

Chemical Name:(1R,2R)-1-(benzo[d][1,3]dioxol-5-yl)-3-(dimethyl(phenyl)silyl)-2-methylbut-3-en-1-ol
CAS No.:1310886-85-1
Molecular Formula:C₂₀H₂₄O₃Si
Molecular Weight:340.494
Hs Code.:

Synonyms:(1R,2R)-1-(benzo[d][1,3]dioxol-5-yl)-3-(dimethyl(phenyl)silyl)-2-methylbut-3-en-1-ol

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Chemical Property of (1R,2R)-1-(benzo[d][1,3]dioxol-5-yl)-3-(dimethyl(phenyl)silyl)-2-methylbut-3-en-1-ol

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Technology Process of (1R,2R)-1-(benzo[d][1,3]dioxol-5-yl)-3-(dimethyl(phenyl)silyl)-2-methylbut-3-en-1-ol

There total 3 articles about (1R,2R)-1-(benzo[d][1,3]dioxol-5-yl)-3-(dimethyl(phenyl)silyl)-2-methylbut-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 120-57-0,30024-74-9
piperonal

: 103223-44-5
(buta-1,3-dien-2-yl)dimethyl(phenyl)silane

: 1310886-85-1
(1R,2R)-1-(benzo[d][1,3]dioxol-5-yl)-3-(dimethyl(phenyl)silyl)-2-methylbut-3-en-1-ol

Guidance literature:: With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); (R)-segphos; In isopropyl alcohol; toluene; at 95 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1021/ja2046028

Reference yield: 88.0%

: 495-76-1
piperonol

: 103223-44-5
(buta-1,3-dien-2-yl)dimethyl(phenyl)silane

: 1310886-85-1
(1R,2R)-1-(benzo[d][1,3]dioxol-5-yl)-3-(dimethyl(phenyl)silyl)-2-methylbut-3-en-1-ol

Guidance literature:: With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); (R)-segphos; In toluene; at 95 ℃; for 4h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Sealed vial; Microwave irradiation;
DOI:10.1021/ja2046028

Reference yield:

: 768-33-2
phenyldimethylsilyl chloride

: 1310886-85-1
(1R,2R)-1-(benzo[d][1,3]dioxol-5-yl)-3-(dimethyl(phenyl)silyl)-2-methylbut-3-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium / tetrahydrofuran / Reflux; Inert atmosphere

2: (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); (R)-segphos / isopropyl alcohol; toluene / 48 h / 95 °C / Inert atmosphere; Sealed tube

With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); magnesium; (R)-segphos; In tetrahydrofuran; isopropyl alcohol; toluene;
DOI:10.1021/ja2046028