(+/-)-7-methoxy-2-(2-methoxybenzyl)-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(+/-)-7-methoxy-2-(2-methoxybenzyl)-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:1349704-32-0
Molecular Formula:C₁₉H₂₄N₂O₅S
Molecular Weight:392.476
Hs Code.:

Synonyms:(+/-)-7-methoxy-2-(2-methoxybenzyl)-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-7-methoxy-2-(2-methoxybenzyl)-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (+/-)-7-methoxy-2-(2-methoxybenzyl)-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

There total 12 articles about (+/-)-7-methoxy-2-(2-methoxybenzyl)-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1349704-31-9
(+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline

: 1349704-32-0
(+/-)-7-methoxy-2-(2-methoxybenzyl)-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; toluene; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/cmdc.201300412

Reference yield:

: 321125-47-7
(+/-)-2-benzyloxy-1-methoxy-4-(2-nitropropyl)benzene

: 1349704-32-0
(+/-)-7-methoxy-2-(2-methoxybenzyl)-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: nickel; hydrazine / methanol / 18 h / 0 - 40 °C

2: triethylamine / dichloromethane / 24 h / 0 - 20 °C

3: toluene-4-sulfonic acid / toluene / 22 h / 120 °C

4: water; potassium hydroxide / ethanol / 66 h / 120 °C

5: triethylamine / ethanol / 130 °C / Microwave irradiation

6: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 130 °C / Microwave irradiation

7: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With palladium 10% on activated carbon; sulphamoyl chloride; water; hydrogen; nickel; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; hydrazine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; toluene;
DOI:10.1021/ml200232c

Reference yield:

: 1064202-09-0
(+/-)-2-acetyl-6-benzyloxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

: 1349704-32-0
(+/-)-7-methoxy-2-(2-methoxybenzyl)-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: water; potassium hydroxide / ethanol / 66 h / 120 °C

2: triethylamine / ethanol / 130 °C / Microwave irradiation

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 130 °C / Microwave irradiation

4: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With palladium 10% on activated carbon; sulphamoyl chloride; water; hydrogen; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide;
DOI:10.1021/ml200232c