(+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1349704-31-9
Molecular Formula:C₁₉H₂₃NO₃
Molecular Weight:313.397
Hs Code.:

Synonyms:(+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of (+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of (+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline

There total 10 articles about (+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (+/-)-7-methoxy-2-(2-methoxybenzyl)-3-methyl-6-(triisopropylsilyloxy)-1,2,3,4-tetrahydroisoquinoline

: 1349704-31-9
(+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1002/cmdc.201300412

Reference yield:

: C₂₆H₂₉NO₃

: 1349704-31-9
(+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 130 ℃; Microwave irradiation;
DOI:10.1021/ml200232c

Reference yield:

: 1064202-09-0
(+/-)-2-acetyl-6-benzyloxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

: 1349704-31-9
(+/-)-6-hydroxy-7-methoxy-2-(2-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: water; potassium hydroxide / ethanol / 66 h / 120 °C

2: triethylamine / ethanol / 130 °C / Microwave irradiation

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 130 °C / Microwave irradiation

With palladium 10% on activated carbon; water; hydrogen; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1021/ml200232c