N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)amino)-6-methoxy-2-naphthamide

Base Information

Chemical Name:N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)amino)-6-methoxy-2-naphthamide
CAS No.:1622104-85-1
Molecular Formula:C₂₅H₂₆N₂O₄
Molecular Weight:418.492
Hs Code.:

Synonyms:N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)amino)-6-methoxy-2-naphthamide

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Chemical Property of N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)amino)-6-methoxy-2-naphthamide

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Technology Process of N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)amino)-6-methoxy-2-naphthamide

There total 4 articles about N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)amino)-6-methoxy-2-naphthamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1622104-84-0
N-(4-(1,3-dioxolan-2-yl)phenyl)-4-bromo-6-methoxy-2-naphthamide

: 2516-47-4
cyclopropanemethylamine

: 1622104-85-1
N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)amino)-6-methoxy-2-naphthamide

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; tert-butyl alcohol; at 125 ℃; for 22h; Inert atmosphere;

Reference yield:

: 1622104-82-8
1-(4-bromo-6-methoxynaphthalen-2-yl)ethanone

: 1622104-85-1
N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)amino)-6-methoxy-2-naphthamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hypochlorite; sodium hydroxide / 1,4-dioxane; water / 10 h / 75 °C / Inert atmosphere

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 5 h / 20 °C

2.2: 20 °C

3.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / toluene; tert-butyl alcohol / 22 h / 125 °C / Inert atmosphere

With sodium hypochlorite; oxalyl dichloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 83710-61-6
1-bromo-7-methoxy-naphthalene

: 1622104-85-1
N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)amino)-6-methoxy-2-naphthamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / dichloromethane; nitromethane / 0.33 h / 0 °C

1.2: 2.5 h / 0 °C

2.1: sodium hypochlorite; sodium hydroxide / 1,4-dioxane; water / 10 h / 75 °C / Inert atmosphere

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 5 h / 20 °C

3.2: 20 °C

4.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / toluene; tert-butyl alcohol / 22 h / 125 °C / Inert atmosphere

With aluminum (III) chloride; sodium hypochlorite; oxalyl dichloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In 1,4-dioxane; nitromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;