Technology Process of N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)(methyl)amino)-6-methoxy-2-naphthamide
There total 5 articles about N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)(methyl)amino)-6-methoxy-2-naphthamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(4-(1,3-dioxolan-2-yl)phenyl)-4-((cyclopropylmethyl)amino)-6-methoxy-2-naphthamide; methyl iodide;
With
cesium fluoride;
In
acetonitrile;
at 82 ℃;
for 22h;
With
hydrogenchloride;
In
1,4-dioxane; water;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hypochlorite; sodium hydroxide / 1,4-dioxane; water / 10 h / 75 °C / Inert atmosphere
2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 5 h / 20 °C
2.2: 20 °C
3.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / toluene; tert-butyl alcohol / 22 h / 125 °C / Inert atmosphere
4.1: cesium fluoride / acetonitrile / 22 h / 82 °C
4.2: 2.5 h
With
sodium hypochlorite; oxalyl dichloride; palladium diacetate; caesium carbonate; cesium fluoride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / dichloromethane; nitromethane / 0.33 h / 0 °C
1.2: 2.5 h / 0 °C
2.1: sodium hypochlorite; sodium hydroxide / 1,4-dioxane; water / 10 h / 75 °C / Inert atmosphere
3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 5 h / 20 °C
3.2: 20 °C
4.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / toluene; tert-butyl alcohol / 22 h / 125 °C / Inert atmosphere
5.1: cesium fluoride / acetonitrile / 22 h / 82 °C
5.2: 2.5 h
With
aluminum (III) chloride; sodium hypochlorite; oxalyl dichloride; palladium diacetate; caesium carbonate; cesium fluoride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide;
In
1,4-dioxane; nitromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
