2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid

Base Information

• Chemical Name: 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid
• CAS No.: 1237515-04-6
• Molecular Formula: C₂₆H₁₉NO₄
• Molecular Weight: 409.441
• Mol file: 1237515-04-6.mol

Synonyms:2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid

Chemical Property of 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid

There total 5 articles about 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoate (1237519-46-8) → 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid (1237515-04-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 17h;

Reference yield:

2-acetyloxy-5-bromobenzoic acid (1503-53-3) → 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid (1237515-04-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.1: pyridine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

3.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.75 h / Inert atmosphere; Reflux

3.2: 2 h / 20 °C / Inert atmosphere

4.1: water; sodium hydroxide / 1,4-dioxane; methanol / 1.67 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

With pyridine; oxalyl dichloride; water; sodium hydrogencarbonate; trifluoroacetic acid; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

2-acetoxy-5-bromo-benzoyl chloride (5485-91-6) → 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid (1237515-04-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

2.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.75 h / Inert atmosphere; Reflux

2.2: 2 h / 20 °C / Inert atmosphere

3.1: water; sodium hydroxide / 1,4-dioxane; methanol / 1.67 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

With pyridine; water; sodium hydrogencarbonate; trifluoroacetic acid; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;

upstream raw materials:

tert-butyl 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoate

2-acetyloxy-5-bromobenzoic acid

2-acetoxy-5-bromo-benzoyl chloride

tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate