(E)-3-[2-(2-Carboxymethylenecyclohexyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine

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Chemical Name:(E)-3-[2-(2-Carboxymethylenecyclohexyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine
CAS No.:171051-02-8
Molecular Formula:C₂₅H₂₂N₄O₃
Molecular Weight:426.475
Hs Code.:

Synonyms:(E)-3-[2-(2-Carboxymethylenecyclohexyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine

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Chemical Property of (E)-3-[2-(2-Carboxymethylenecyclohexyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine

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Technology Process of (E)-3-[2-(2-Carboxymethylenecyclohexyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine

There total 7 articles about (E)-3-[2-(2-Carboxymethylenecyclohexyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 171051-36-8
tert-butyl 2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1(6H)-pyridazinyl]-(E)-cyclohexylidene-1-acetate

: 171051-02-8
(E)-3-[2-(2-Carboxymethylenecyclohexyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 5 - 20 ℃;
DOI:10.1016/S0968-0896(99)00258-8

Reference yield:

: 131185-06-3
3-(3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo<1,5-a>pyridine

: 171051-02-8
(E)-3-[2-(2-Carboxymethylenecyclohexyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water; toluene / 6 h

2: triethylamine; sulfur trioxide pyridine complex / dichloromethane

3: sodium hydroxide; potassium carbonate / 1,2-dimethoxyethane / 8 h / 25 °C

4: sodium hydroxide; methanol / 55 °C

With methanol; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; sodium hydroxide; In 1,2-dimethoxyethane; dichloromethane; water; toluene; 2: |Parikh-Doering Oxidation / 3: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/op990066i

Reference yield:

: 3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-(6H)-pyridazin-6-one-1-cyclohexan-2-ol

: 171051-02-8
(E)-3-[2-(2-Carboxymethylenecyclohexyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: dimethyl sulfoxide; triethylamine; dichloromethane; sulfur trioxide pyridine complex / 4 h / 3 - 20 °C / Large scale

2: sodium hydroxide; potassium carbonate / dimethyl sulfoxide / 2 h / 50 °C

3: sodium hydroxide; methanol / 55 °C

With methanol; dichloromethane; sulfur trioxide pyridine complex; potassium carbonate; dimethyl sulfoxide; triethylamine; sodium hydroxide; In dimethyl sulfoxide; 1: |Swern Oxidation / 2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/op990066i