1-phenylcyclohexanecarboxamide

Base Information

• Chemical Name: 1-phenylcyclohexanecarboxamide
• CAS No.: 2890-60-0
• Molecular Formula: C13H17 N O
• Molecular Weight: 203.284
• Mol file: 2890-60-0.mol

Synonyms:

Chemical Property of 1-phenylcyclohexanecarboxamide

Chemical Property:

• Vapor Pressure: 3.34E-06mmHg at 25°C
• Boiling Point: 387.3°Cat760mmHg
• Flash Point: 188°C
• Density: 1.084g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-phenylcyclohexanecarboxamide

There total 6 articles about 1-phenylcyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-phenyl-1-cyclohexanecarbonitrile (2201-23-2) → 1-phenylcyclohexane-1-carboxamide (2890-60-0)

Guidance literature:

With sulfuric acid; trifluoroacetic acid; for 14h;

DOI:10.1007/s11094-019-01950-z

Reference yield:

1-phenylcyclohexylcarbonyl chloride (2890-42-8) → 1-phenylcyclohexane-1-carboxamide (2890-60-0)

Guidance literature:

With ammonium hydroxide;

Reference yield:

1-phenyl-cyclohexanecarboxylic acid (1135-67-7) → 1-phenylcyclohexane-1-carboxamide (2890-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dimethylformamide / 2 h

2: ammonia (g) / propan-2-ol / 0.33 h

With thionyl chloride; ammonia; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm00167a027

upstream raw materials:

1-phenylcyclohexylcarbonyl chloride

1-phenyl-1-cyclohexanecarbonitrile

1,5-dibromo-pentane

1-phenyl-cyclohexanecarboxylic acid

Downstream raw materials:

IEM 1921

1-phenylcyclohexylamine

1-phenyl-1-cyclohexanecarbonitrile

1-amino-2-phenyl-2,2-pentamethyleneethane