2890-42-8

Basic information

• Product Name: Cyclohexanecarbonyl chloride, 1-phenyl-
• Synonyms: Cyclohexanecarbonyl chloride, 1-phenyl- ;1-PHENYL-CYCLOHEXANECARBONYL CHLORIDE
• CAS NO: 2890-42-8
• Molecular Formula: C₁₃H₁₅ClO
• Molecular Weight: 222.72
• Mol File: 2890-42-8.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclohexanecarbonyl chloride, 1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarbonyl chloride, 1-phenyl-(2890-42-8)
• EPA Substance Registry System: Cyclohexanecarbonyl chloride, 1-phenyl-(2890-42-8)

Safety Data

• Hazardous Substances Data: 2890-42-8(Hazardous Substances Data)

Upstream product

• 1135-67-7 1-phenyl-cyclohexanecarboxylic acid 
• 111-24-0 1,5-dibromo-pentane 
• 140-29-4 phenylacetonitrile 
• 17380-78-8 methyl 1-phenyl-1-cyclohexanecarboxylate 
• 101-41-7 benzeneacetic acid methyl ester 
• 2201-23-2 1-phenyl-1-cyclohexanecarbonitrile 

Downstream Products

• 101498-75-3 2-methoxy-1-(1-phenyl-cyclohexyl)-ethanone 
• 102314-51-2 1-phenyl-cyclohexanecarboxylic acid-[2-(4-methyl-piperazino)-ethyl ester] 
• 3183-57-1 1-(1-phenylcyclohexyl)ethanone 
• 41848-75-3 phenyl-(1-phenyl-cyclohexyl)-ketone 
• 13877-96-8 UCB 597 
• 136089-21-9 N-<2-<2-(diethylamino)ethoxy>ethyl>-1-phenyl-1-cyclohexanecarboxamide 
• 88043-24-7 ((2S,4S)-4-tert-Butylsulfanyl-2-methoxymethyl-pyrrolidin-1-yl)-(1-phenyl-cyclohexyl)-methanone 
• 2886-61-5 1-<1-Phenyl-cyclohexyl>-propan-1-on 
• 2891-54-5 2-Methyl-1-<1-phenyl-cyclohexyl>-propan-1-on 
• 551944-30-0 N-[(4β,5α)-12-(Benzyloxy)-16-oxopodocarpa-8,11,13-trien-16-yl]-1-phenylcyclohexanecarboxamide 
• 874895-86-0 4,4-dimethyl-2-(1-phenylcyclohexyl)oxazoline 
• 914106-86-8 N-(2'-aminophenyl)-(1-(phenyl)cyclohex-1-yl)carboxamide 

Relevant articles and documents

Amide compound and derivative thereof, preparation method, pharmaceutical composition and application thereof

The invention discloses an amide compound and derivative thereof, a preparation method, a pharmaceutical composition and application thereof. The structure of the amide compound is shown as a formula (I). The derivatives of theamide compound relate to a stereoisomer, a tautomer, a metabolite, a metabolic precursor, a prodrug, a solvate, a salt of the solvate, a crystal, a pharmaceutically acceptable salt or a mixture of the above of theamide compound. The amide compound and the derivative thereof have an efficient inhibition effect on indoleamine 2, 3-dioxygenase 1, and can be used for preparing medicines for treating indoleamine 2, 3-dioxygenase 1 mediated immunosuppression related diseases, the prepared medicine can exert the medicine effect at the molecular level and is wide in application, and the synthesis method of the compound is simple, convenient and easy to operate.

Switchable Synthesis of Z-Homoallylic Boronates and E-Allylic Boronates by Enantioselective Copper-Catalyzed 1,6-Boration

The enantioselective Cu-catalyzed 1,6-boration of (E,E)-α,β,γ,δ-unsaturated ketones is described, which gives homoallylic boronates with high enantiomeric purity and unexpectedly high Z-selectivity. By changing the solvent, the outcome can be altered to give E-allylic boronates.

Remote C-H bond functionalization reveals the distance-dependent isotope effect

Iodination of remote aryl C-H bonds has been achieved using palladium acetate as the catalyst and iodoacetate (IOAc) as the oxidant. Systematic kinetic isotope studies imply a mechanistic regime shift as the number of bonds separating the directing heteroatom and the target C-H bond increases. Both isotope and electronic effects observed in remote C-H bond activation are consistent with an electrophilic palladation pathway in which the initial palladation is slower than the C-H bond cleavage.