(S)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-((1-acetyl)azetidin-3-yl)oxime

Base Information

Chemical Name:(S)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-((1-acetyl)azetidin-3-yl)oxime
CAS No.:1433609-09-6
Molecular Formula:C₂₅H₂₅FN₆O₂
Molecular Weight:460.511
Hs Code.:

Synonyms:(S)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-((1-acetyl)azetidin-3-yl)oxime

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Chemical Property of (S)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-((1-acetyl)azetidin-3-yl)oxime

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Technology Process of (S)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-((1-acetyl)azetidin-3-yl)oxime

There total 6 articles about (S)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-((1-acetyl)azetidin-3-yl)oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1433608-87-7
(S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(azetidin-3-yl)oxime

: 75-36-5
acetyl chloride

: 1433609-09-6
(S)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-((1-acetyl)azetidin-3-yl)oxime

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1433605-21-0
(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

: 1433609-09-6
(S)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-((1-acetyl)azetidin-3-yl)oxime

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: butan-1-ol / tetrahydrofuran / 36 h / 30 °C / Enzymatic reaction

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 50 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

5: triethylamine / dichloromethane / 2 h / 20 °C

With sodium hydride; triethylamine; trifluoroacetic acid; butan-1-ol; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: (E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-acetyl oxime

: 1433609-09-6
(S)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-((1-acetyl)azetidin-3-yl)oxime

Guidance literature:: Multi-step reaction with 4 steps

1: butan-1-ol / tetrahydrofuran / 36 h / 30 °C / Enzymatic reaction

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 50 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

4: triethylamine / dichloromethane / 2 h / 20 °C

With sodium hydride; triethylamine; trifluoroacetic acid; butan-1-ol; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;