methyl 3-amino-4-<(2-methoxycarbonyl)phenylsulfonyl>-2-thiophenecarboxylate

Base Information

Chemical Name:methyl 3-amino-4-<(2-methoxycarbonyl)phenylsulfonyl>-2-thiophenecarboxylate
CAS No.:243984-68-1
Molecular Formula:C₁₄H₁₃NO₆S₂
Molecular Weight:355.392
Hs Code.:

Synonyms:methyl 3-amino-4-<(2-methoxycarbonyl)phenylsulfonyl>-2-thiophenecarboxylate

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Chemical Property of methyl 3-amino-4-<(2-methoxycarbonyl)phenylsulfonyl>-2-thiophenecarboxylate

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Technology Process of methyl 3-amino-4-<(2-methoxycarbonyl)phenylsulfonyl>-2-thiophenecarboxylate

There total 6 articles about methyl 3-amino-4-<(2-methoxycarbonyl)phenylsulfonyl>-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 2365-48-2
Methyl thioglycolate

: 3-ethoxy-2-<(2-methoxycarbonyl)phenylsulfonyl>acrylonitrile

: 243984-68-1
methyl 3-amino-4-<(2-methoxycarbonyl)phenylsulfonyl>-2-thiophenecarboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 75 - 80 ℃; for 2h;
DOI:10.1002/jhet.5570360314

Reference yield:

: 243984-86-3
2-(cyanomethylthio)benzoic acid

: 243984-68-1
methyl 3-amino-4-<(2-methoxycarbonyl)phenylsulfonyl>-2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / 35 percent aq. H₂O₂, AcOH / 6 h / 100 °C

2: thionyl chloride / 2 h / 60 °C

3: 0.75 h / 60 °C

4: 90 percent / Ac₂O, ZnCl₂ / 125 - 130 °C

5: 50 percent / Et₃N / tetrahydrofuran / 2 h / 75 - 80 °C

With thionyl chloride; dihydrogen peroxide; acetic anhydride; acetic acid; triethylamine; zinc(II) chloride; In tetrahydrofuran;
DOI:10.1002/jhet.5570360314

Reference yield:

: 147-93-3
Thiosalicylic acid

: 243984-68-1
methyl 3-amino-4-<(2-methoxycarbonyl)phenylsulfonyl>-2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / aq. NaOH / 1 h / Ambient temperature

2: 83 percent / 35 percent aq. H₂O₂, AcOH / 6 h / 100 °C

3: thionyl chloride / 2 h / 60 °C

4: 0.75 h / 60 °C

5: 90 percent / Ac₂O, ZnCl₂ / 125 - 130 °C

6: 50 percent / Et₃N / tetrahydrofuran / 2 h / 75 - 80 °C

With sodium hydroxide; thionyl chloride; dihydrogen peroxide; acetic anhydride; acetic acid; triethylamine; zinc(II) chloride; In tetrahydrofuran;
DOI:10.1002/jhet.5570360314