4-(azetidin-1-yl)-7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]-triazine

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Chemical Name:4-(azetidin-1-yl)-7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]-triazine
CAS No.:1394033-66-9
Molecular Formula:C₂₀H₁₈F₃N₇
Molecular Weight:413.405
Hs Code.:

Synonyms:4-(azetidin-1-yl)-7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]-triazine

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Chemical Property of 4-(azetidin-1-yl)-7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]-triazine

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Technology Process of 4-(azetidin-1-yl)-7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]-triazine

There total 3 articles about 4-(azetidin-1-yl)-7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 503-29-7
azetidine

: 1394034-73-1
7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one

: 1394033-66-9
4-(azetidin-1-yl)-7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]-triazine

Guidance literature:: 7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]triazin-4(3H)-one; With 1,2,4-Triazole; triethylamine; trichlorophosphate; In dichloromethane; at 0 - 23 ℃; for 4h; Inert atmosphere;

azetidine; With caesium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01466

Reference yield:

: 1394034-59-3
2-bromo-1-(5-bromo-1-methyl-1H-pyrazol-4-yl)ethanone

: 1394033-66-9
4-(azetidin-1-yl)-7-methyl-5-(1-methyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)imidazo[5,1-f ][1,2,4]-triazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane; 2-methyltetrahydrofuran / 2.5 h / Inert atmosphere; Reflux

2.1: dichloromethane / 2.5 h / 23 °C / Inert atmosphere

3.1: iso-butanol / 24 h / 20 - 100 °C / Inert atmosphere

4.1: 1,4-dioxane / 6.25 h / 23 - 50 °C / Inert atmosphere

5.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 3.16 h / 20 °C / Inert atmosphere; Reflux

6.1: 1,2,4-Triazole; trichlorophosphate; triethylamine / dichloromethane / 4 h / 0 - 23 °C / Inert atmosphere

6.2: 1 h / 23 °C / Inert atmosphere

With 1,2,4-Triazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; isopropyl alcohol; iso-butanol; 5.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01466