N-phenylnaphtho[2,1-d]thiazol-2-amine

Base Information

• Chemical Name: N-phenylnaphtho[2,1-d]thiazol-2-amine
• CAS No.: 110333-86-3
• Molecular Formula: C₁₇H₁₂N₂S
• Molecular Weight: 276.362
• Mol file: 110333-86-3.mol

Synonyms:N-phenylnaphtho[2,1-d]thiazol-2-amine

Chemical Property of N-phenylnaphtho[2,1-d]thiazol-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-phenylnaphtho[2,1-d]thiazol-2-amine

There total 6 articles about N-phenylnaphtho[2,1-d]thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-naphthyl isothiocyanate (1636-33-5) + aniline (62-53-3) → N-phenylnaphtho[2,1-d]thiazol-2-amine (110333-86-3)

Guidance literature:

With eosin; oxygen; In dimethyl sulfoxide; at 25 ℃; for 24h; regioselective reaction; Schlenk technique; Sealed tube; Irradiation; Green chemistry;

DOI:10.1007/s11426-020-9811-6

Reference yield: 79.0%

1,2,3,4-tetrahydronaphthalen-2-one (530-93-8) + monophenylthiourea (103-85-5) → N-phenylnaphtho[2,1-d]thiazol-2-amine (110333-86-3)

Guidance literature:

With iodine; oxygen; toluene-4-sulfonic acid; In dimethyl sulfoxide; at 75 ℃; for 24h; under 760.051 Torr;

DOI:10.1021/ol400773k

Reference yield:

2-naphthyl isothiocyanate (1636-33-5) → N-phenylnaphtho[2,1-d]thiazol-2-amine (110333-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₅ / 160 - 180 °C

With phosphorus pentachloride;

DOI:10.1039/jr9300000941

upstream raw materials:

1-naphthalen-2-yl-3-phenyl-thiourea

2-chloronaphtho<2,1-d>thiazole

aniline

2-naphthyl isothiocyanate

Downstream raw materials:

N-methyl-N-phenylnaphtho[2,1-d]thiazol-2-amine

(3-methyl-3H-naphtho[2,1-d]thiazol-2-ylidene)-phenyl-amine