Technology Process of cyclodi(L-3-iodotyrosine)
There total 5 articles about cyclodi(L-3-iodotyrosine) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-tert-butoxycarbonyl-L-3-iodotyrosyl-L-3-iodotyrosine methyl ester;
With
formic acid;
for 2h;
In
toluene; iso-butanol;
for 3h;
Reflux;
DOI:10.1021/ol300831t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / 16 h / Reflux
2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / Inert atmosphere
3.1: formic acid / 2 h
3.2: 3 h / Reflux
With
formic acid; thionyl chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
N,N-dimethyl-formamide;
DOI:10.1021/ol300831t
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / Inert atmosphere
2.1: formic acid / 2 h
2.2: 3 h / Reflux
With
formic acid; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
N,N-dimethyl-formamide;
DOI:10.1021/ol300831t
