6-[18F]fluoro-3,4-dimethoxybenzyl bromide

Base Information

• Chemical Name: 6-[18F]fluoro-3,4-dimethoxybenzyl bromide
• CAS No.: 136297-37-5
• Molecular Formula: C₉H₁₀BrFO₂
• Molecular Weight: 248.081
• Mol file: 136297-37-5.mol

Synonyms:6-[18F]fluoro-3,4-dimethoxybenzyl bromide

Chemical Property of 6-[18F]fluoro-3,4-dimethoxybenzyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[18F]fluoro-3,4-dimethoxybenzyl bromide

There total 3 articles about 6-[18F]fluoro-3,4-dimethoxybenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-[18F]fluoro-4,5-dimethoxyphenyl)methanol (136297-35-3) → 6-[18F]fluoro-3,4-dimethoxybenzyl bromide (136297-37-5)

Guidance literature:

With hydrogen bromide;

Reference yield:

2-[18F]fluoro-4,5-dimethoxybenzaldehyde (129841-06-1) → 6-[18F]fluoro-3,4-dimethoxybenzyl bromide (136297-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / water / 0.03 h / Solid phase extraction cartridge

2: hydrogen bromide / water / 0.03 h / 20 °C / Solid phase extraction cartridge

With sodium tetrahydroborate; hydrogen bromide; In water;

DOI:10.1016/j.jfluchem.2012.03.015

Reference yield:

6-nitroveratraldehyde (20357-25-9) → 6-[18F]fluoro-3,4-dimethoxybenzyl bromide (136297-37-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride / water; dimethyl sulfoxide / 0.25 h / 140 °C

2: sodium tetrahydroborate / water / 0.03 h / Solid phase extraction cartridge

3: hydrogen bromide / water / 0.03 h / 20 °C / Solid phase extraction cartridge

With sodium tetrahydroborate; 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; hydrogen bromide; In water; dimethyl sulfoxide;

DOI:10.1016/j.jfluchem.2012.03.015

upstream raw materials:

(2-[¹⁸F]fluoro-4,5-dimethoxyphenyl)methanol

2-[¹⁸F]fluoro-4,5-dimethoxybenzaldehyde

6-nitroveratraldehyde

Downstream raw materials:

C₂₈H₃₀⁽¹⁸⁾FNO₄