136297-35-3Relevant academic research and scientific papers
Highly enantioselective synthesis of no-carrier-added 6-[ 18F]fluoro-L-dopa by chiral phase-transfer alkylation
Lemaire, Christian,Gillet, Steve,Guillouet, Stephane,Plenevaux, Alain,Aerts, Joel,Luxen, Andre
, p. 2899 - 2904 (2004)
[18F]Fluoro-L-dopa, an important radiopharmaceutical for positron emission tomography (PET), has been synthesized using a phase-transfer alkylation reaction. A chiral quaternary ammonium salt derived from a Cinchona alkaloid served as phase-tra
Method for preparing [18F]Fluoro-L-Dopa with high radiochemical and enantiomeric purity
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Paragraph 0021; 0022; 0053-0056, (2017/01/12)
The present invention relates to a manufacturing method and a purifying method of [^18f] fluoro-L-dopa with high purity and high specific radioactivity, which is automatically manufactured wherein the [^18f] fluoro-L-dopa requires at least one solution process in each manufacturing step and accordingly has good reproducibility and stable yield, thereby being used in an auto-manufacturing apparatus, and is purified by using a high performance liquid chromatography which uses a solid phase extraction method and chiral column, thereby having good high purity and high specific radioactivity.
Automated production at the curie level of no-carrier-added 6-[18F]fluoro- l -dopa and 2-[18F]fluoro- l -tyrosine on a FASTlab synthesizer
Lemaire,Libert,Franci,Genon,Kuci,Giacomelli,Luxen
, p. 281 - 290 (2015/06/25)
An efficient, fully automated, enantioselective multi-step synthesis of no-carrier-added (nca) 6-[18F]fluoro-L-dopa ([18F]FDOPA) and 2-[18F]fluoro-L-tyrosine ([18F]FTYR) on a GE FASTlab synthesizer in conjunctio
Fast and reliable method for the preparation of ortho- and para-[ 18F]fluorobenzyl halide derivatives: Key intermediates for the preparation of no-carrier-added PET aromatic radiopharmaceuticals
Lemaire, Christian,Libert, Lionel,Plenevaux, Alain,Aerts, Jo?l,Franci, Xavier,Luxen, André
experimental part, p. 48 - 55 (2012/06/18)
A fast and reliable method suitable for the automated preparation of (substituted) [18F]fluorobenzyl halides from several [ 18F]fluorobenzaldehydes was developed. Aromatic nucleophilic substitution of trimethylammonium benzaldehyde t
