2-cyclopropyl-5-phenyl-thiazole-4-carboxylic acid [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-amide

Base Information

Chemical Name:2-cyclopropyl-5-phenyl-thiazole-4-carboxylic acid [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-amide
CAS No.:1258458-56-8
Molecular Formula:C₂₂H₁₉N₅O₃S
Molecular Weight:433.491
Hs Code.:

Synonyms:2-cyclopropyl-5-phenyl-thiazole-4-carboxylic acid [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-amide

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Chemical Property of 2-cyclopropyl-5-phenyl-thiazole-4-carboxylic acid [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-amide

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Technology Process of 2-cyclopropyl-5-phenyl-thiazole-4-carboxylic acid [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-amide

There total 6 articles about 2-cyclopropyl-5-phenyl-thiazole-4-carboxylic acid [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258459-41-4
[2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-(2-cyclopropyl-5-phenyl-thiazole-4-carbonyl)-carbamic acid tert-butyl ester

: 1258458-56-8
2-cyclopropyl-5-phenyl-thiazole-4-carboxylic acid [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-amide

Guidance literature:: [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-(2-cyclopropyl-5-phenyl-thiazole-4-carbonyl)-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 936128-54-0
2-cyclopropyl-5-phenyl-1,3-thiazole-4-carboxylic acid

: 1258458-56-8
2-cyclopropyl-5-phenyl-thiazole-4-carboxylic acid [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere

2.2: 16.5 h / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; sodium hydride; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1258458-95-5
2-(3-acetyl-pyrazol-1-ylmethyl)-oxazole-4-carboxylic acid

: 1258458-56-8
2-cyclopropyl-5-phenyl-thiazole-4-carboxylic acid [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 4 h / 20 °C / Inert atmosphere

2.1: sodium azide / water; acetone / 0.5 h / 0 - 20 °C / Inert atmosphere

3.1: xylene / 0.08 h / 140 °C / Inert atmosphere

3.2: 0.08 h / 140 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere

4.2: 16.5 h / 0 - 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With sodium azide; oxalyl dichloride; sodium hydride; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; acetone; toluene; xylene; 3.1: Curtius Rearrangement;