Technology Process of 2-[(1R,2S,4R)-4-Benzyloxymethyl-2-(2-hydroxy-ethoxy)-cyclopentyloxy]-ethanol
There total 6 articles about 2-[(1R,2S,4R)-4-Benzyloxymethyl-2-(2-hydroxy-ethoxy)-cyclopentyloxy]-ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaClO3, NaHCO3, OsO4; 2.) and 3) conc. H2SO4 / 1.) H2O, 70 deg C, 11 h; 2.) reflux; 3.) reflux, 1 h
2: 92 percent / LiAlH4 / tetrahydrofuran / Ambient temperature
3: 1.) NaH / 1.) DMF; 2.) 2h, 0 deg C, then room temp.
4: 100 percent / conc. aq. HCl / tetrahydrofuran; H2O / 96 h
5: 1.) Potassium tert-butoxide, 2.) LiAlH4 / 1.) THF, room temp., 3 days, 2.) THF, room temp.
With
hydrogenchloride; sodium chlorate; osmium(VIII) oxide; lithium aluminium tetrahydride; sulfuric acid; potassium tert-butylate; sodium hydride; sodium hydrogencarbonate;
In
tetrahydrofuran; water;
DOI:10.1021/jo00329a011
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF; 2.) 2h, 0 deg C, then room temp.
2: 100 percent / conc. aq. HCl / tetrahydrofuran; H2O / 96 h
3: 1.) Potassium tert-butoxide, 2.) LiAlH4 / 1.) THF, room temp., 3 days, 2.) THF, room temp.
With
hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; sodium hydride;
In
tetrahydrofuran; water;
DOI:10.1021/jo00329a011
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF; 2.) 2h, 0 deg C, then room temp.
2: 100 percent / conc. aq. HCl / tetrahydrofuran; H2O / 96 h
3: 1.) Potassium tert-butoxide, 2.) LiAlH4 / 1.) THF, room temp., 3 days, 2.) THF, room temp.
With
hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; sodium hydride;
In
tetrahydrofuran; water;
DOI:10.1021/jo00329a011
