(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxy-8-methylquinolin-6-yl)bis(1-methyl-1H-imidazol-5-yl)methanol

Base Information

Chemical Name:(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxy-8-methylquinolin-6-yl)bis(1-methyl-1H-imidazol-5-yl)methanol
CAS No.:1599530-93-4
Molecular Formula:C₃₀H₂₈ClN₇O₂
Molecular Weight:554.051
Hs Code.:

Synonyms:(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxy-8-methylquinolin-6-yl)bis(1-methyl-1H-imidazol-5-yl)methanol

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Chemical Property of (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxy-8-methylquinolin-6-yl)bis(1-methyl-1H-imidazol-5-yl)methanol

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Technology Process of (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxy-8-methylquinolin-6-yl)bis(1-methyl-1H-imidazol-5-yl)methanol

There total 3 articles about (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxy-8-methylquinolin-6-yl)bis(1-methyl-1H-imidazol-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41806-40-0
1-methyl-1H-imidazole-5-carboxylic acid

: 1599530-93-4
(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxy-8-methylquinolin-6-yl)bis(1-methyl-1H-imidazol-5-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 20 °C

2.1: ethylmagnesium bromide / dichloromethane; diethyl ether / 0.42 h / 20 °C

2.2: 48 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.28 h / -78 - 0 °C

3.2: 20 °C

With n-butyllithium; ethylmagnesium bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;

Reference yield:

: 1599529-09-5
3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxy-8-methylquinoline

: 406216-47-5
bis(1-methyl-1H-imidazol-5-yl)methanone

: 1599530-93-4
(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxy-8-methylquinolin-6-yl)bis(1-methyl-1H-imidazol-5-yl)methanol

Guidance literature:: 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxy-8-methylquinoline; bis(1-methyl-1H-imidazol-5-yl)methanone; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.283333h;

With water; ammonium chloride; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield:

: 592554-79-5
3-methyl-3H-imidazole-4-carboxylic acid methoxy(methyl)amide

: 1599530-93-4
(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxy-8-methylquinolin-6-yl)bis(1-methyl-1H-imidazol-5-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethylmagnesium bromide / dichloromethane; diethyl ether / 0.42 h / 20 °C

1.2: 48 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.28 h / -78 - 0 °C

2.2: 20 °C

With n-butyllithium; ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;