1-{3-[3-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]piperidin-1-yl}-2-[4-(trifluoromethyl)phenyl]ethanone

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Chemical Name:1-{3-[3-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]piperidin-1-yl}-2-[4-(trifluoromethyl)phenyl]ethanone
CAS No.:1350880-18-0
Molecular Formula:C₂₇H₂₃F₄N₅O
Molecular Weight:509.506
Hs Code.:

Synonyms:1-{3-[3-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]piperidin-1-yl}-2-[4-(trifluoromethyl)phenyl]ethanone

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Chemical Property of 1-{3-[3-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]piperidin-1-yl}-2-[4-(trifluoromethyl)phenyl]ethanone

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Technology Process of 1-{3-[3-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]piperidin-1-yl}-2-[4-(trifluoromethyl)phenyl]ethanone

There total 6 articles about 1-{3-[3-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]piperidin-1-yl}-2-[4-(trifluoromethyl)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350881-12-7
2-[3-(4-fluorophenyl)-5-(piperidin-3-yl)-1H-pyrazoI-1-yl]pyrimidine

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 1350880-18-0
1-{3-[3-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]piperidin-1-yl}-2-[4-(trifluoromethyl)phenyl]ethanone

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 189442-78-2
(±)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

: 1350880-18-0
1-{3-[3-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]piperidin-1-yl}-2-[4-(trifluoromethyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: methylmagnesium bromide / tetrahydrofuran / 1 h / 0 °C

1.2: 20 °C

2.1: hydrazine / ethanol / 3 h / 75 °C

3.1: caesium carbonate; 1,10-Phenanthroline / copper(l) iodide / toluene / 4 h / 120 °C / Inert atmosphere

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; 1,10-Phenanthroline; methylmagnesium bromide; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; hydrazine; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 71381-75-4,88495-54-9,84358-12-3
N-(tert-butyloxycarbonyl)nipecotic acid

: 1350880-18-0
1-{3-[3-(4-fluorophenyl)-1-(pyrimidin-2-yl)-1H-pyrazol-5-yl]piperidin-1-yl}-2-[4-(trifluoromethyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: methylmagnesium bromide / tetrahydrofuran / 1 h / 0 °C

2.2: 20 °C

3.1: hydrazine / ethanol / 3 h / 75 °C

4.1: caesium carbonate; 1,10-Phenanthroline / copper(l) iodide / toluene / 4 h / 120 °C / Inert atmosphere

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; dmap; 1,10-Phenanthroline; methylmagnesium bromide; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;