189442-78-2

Basic information

• Product Name: 1-Boc-3-[methoxy(methyl)carbamoyl]piperidine
• Synonyms: N-BOC-3-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE;TERT-BUTYL 3-(N-METHOXY-N-METHYLCARBAMOYL)PIPERIDINE-1-CARBOXYLATE;1-BOC-3-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE;3-(Methoxy-methyl-carbamoyl)-piperidine-1-carboxylicacidtert-butylester;tert-Butyl 3-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-[(methoxymethylamino)carbonyl]-,1,1-dimethylethyl ester;1-Boc-N-Methoxy-N-Methylpiperidine-3-carboxaMide;1-Boc-3-(N-Methoxy-N-MethylcarbaMoyl)piperidine
• CAS NO: 189442-78-2
• Molecular Formula: C₁₃H₂₄N₂O₄
• Molecular Weight: 272.34
• Product Categories: pharmacetical
• Mol File: 189442-78-2.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 343.797 °C at 760 mmHg
• Flash Point: 161.723 °C
• Appearance: /
• Density: 1.106 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.50±0.40(Predicted)
• CAS DataBase Reference: 1-Boc-3-[methoxy(methyl)carbamoyl]piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-[methoxy(methyl)carbamoyl]piperidine(189442-78-2)
• EPA Substance Registry System: 1-Boc-3-[methoxy(methyl)carbamoyl]piperidine(189442-78-2)

Safety Data

• Hazardous Substances Data: 189442-78-2(Hazardous Substances Data)

Usage

Description

1-Boc-3-[methoxy(methyl)carbamoyl]piperidine is a chemical compound that belongs to the class of piperidine derivatives. It is a derivative of 1-Boc-3-hydroxypiperidine and contains a 3-methoxy(methyl)carbamoyl group attached to the piperidine ring. 1-Boc-3-[methoxy(methyl)carbamoyl]piperidine has potential applications in medicinal chemistry as a building block for the synthesis of various pharmaceutical compounds. It may also be used as a precursor in the synthesis of other organic compounds. Additionally, it exhibits interesting chemical and pharmacological properties that make it an attractive target for further research and development.

Uses

Used in Pharmaceutical Industry:
1-Boc-3-[methoxy(methyl)carbamoyl]piperidine is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
1-Boc-3-[methoxy(methyl)carbamoyl]piperidine is used as a precursor in the synthesis of other organic compounds. Its versatile structure allows for further chemical modifications and functionalization, enabling the creation of a wide range of organic molecules with diverse properties and applications.
Used in Medicinal Chemistry Research:
1-Boc-3-[methoxy(methyl)carbamoyl]piperidine is used as a subject of research in medicinal chemistry. Its interesting chemical and pharmacological properties make it an attractive target for the exploration of new drug candidates and the understanding of molecular interactions in biological systems.

InChI:InChI=1/C13H24N2O4/c1-13(2,3)19-12(17)15-8-6-7-10(9-15)11(16)14(4)18-5/h10H,6-9H2,1-5H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 816455-27-3 1-(t-butoxycarbonyl)nipecotoyl chloride 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 128625-52-5 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 
• 498-95-3 nipecotic acid 

Downstream Products

• 118156-93-7 3-formylpiperidine-1-carboxylic acid tert-butyl ester 
• 884510-91-2 1,1-dimethylethyl 3-benzoyl-1-piperidinecarboxylate 
• 858643-92-2 tert-butyl 3-acetylpiperidine-1-carboxylate 
• 2637-77-6 1,3-dibenzoyl-piperidine 
• 5562-52-7 3-benzoylpiperidin-1-ium chloride 
• 1380311-66-9 C₂₆H₂₇N₅O₂ 
• 1380311-65-8 C₂₆H₂₇N₅O₂ 
• 1380312-10-6 C₃₁H₃₇N₅O₄ 
• 1380312-09-3 C₃₁H₃₅N₅O₄ 
• 1380312-08-2 C₂₆H₃₅N₃O₆S 
• 1380312-07-1 C₁₉H₂₇NO₅ 
• 1374351-14-0 5-(3-(1-(2-fluoro-6-methoxybenzyl)piperidin-3-yl)-1H-pyrazol-1-yl)-3-(pyridin-4-yl)-1H-indazole 
• 1374353-21-5 tert-butyl 3-(1-(3-(pyridin-4-yl)-1-trityl-1H-indazol-5-yl)-1H-pyrazol-3-yl)piperidine-1-carboxylate 
• 1188264-16-5 tert-butyl 3-(1H-pyrazol-3-yl)piperidine-1-carboxylate 

Relevant articles and documents

Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B

The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological, and oncological disorders. This has promoted increased research into selective MAO-A and MAO-B inhibitors. Here, we shed light on how selective inhibition of MAO-A and MAO-B can be achieved by geometric isomers of cis-and trans-1-propargyl-4-styrylpiperidines. While the cis isomers are potent human MAO-A inhibitors, the trans analogues selectively target only the MAO-B isoform. The inhibition was studied by kinetic analysis, UV-vis spectrum measurements, and X-ray crystallography. The selective inhibition of the MAO-A and MAO-B isoforms was confirmed ex vivo in mouse brain homogenates, and additional in vivo studies in mice show the therapeutic potential of 1-propargyl-4-styrylpiperidines for central nervous system disorders. This study represents a unique case of stereoselective activity of cis/trans isomers that can discriminate between structurally related enzyme isoforms.

[1,2,4]-TRIAZOLO [1,5-A]-PYRIMIDINYL DERIVATIVES SUBSTITUTED WITH PIPERIDINE, MORPHOLINE OR PIPERAZINE AS OGA INHIBITORS

The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C90RF72 mutations.

(PIPERIDIN-3-YL)(NAPHTHALEN-2-YL)METHANONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HISTONE DEMETHYLASE KDM2B FOR THE TREATMENT OF CANCER

The present invention relates to (piperidin-3-yl)(naphthalen-2-yl) methanone derivatives and related compounds as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising