189442-78-2

Usage

Uses

Used in Pharmaceutical Industry:
1-Boc-3-[methoxy(methyl)carbamoyl]piperidine is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
1-Boc-3-[methoxy(methyl)carbamoyl]piperidine is used as a precursor in the synthesis of other organic compounds. Its versatile structure allows for further chemical modifications and functionalization, enabling the creation of a wide range of organic molecules with diverse properties and applications.
Used in Medicinal Chemistry Research:
1-Boc-3-[methoxy(methyl)carbamoyl]piperidine is used as a subject of research in medicinal chemistry. Its interesting chemical and pharmacological properties make it an attractive target for the exploration of new drug candidates and the understanding of molecular interactions in biological systems.

InChI:InChI=1/C13H24N2O4/c1-13(2,3)19-12(17)15-8-6-7-10(9-15)11(16)14(4)18-5/h10H,6-9H2,1-5H3

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 498-95-3 nipecotic acid 
• 128625-52-5 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 816455-27-3 1-(t-butoxycarbonyl)nipecotoyl chloride 

Downstream Products

• 118156-93-7 3-formylpiperidine-1-carboxylic acid tert-butyl ester 
• 744216-06-6 2'-amino-6'-(2-benzyloxy-phenyl)-1-methyl-1,2,3,4,5,6-hexahydro-[3,4']bipyridinyl-3'-carbonitrile 
• 406212-54-2 tert-butyl 3-[2-amino-3-cyano-6-(2-hydroxyphenyl)-4-pyridinyl]-1-piperidinecarboxylate 
• 744216-09-9 3'-cyano-6'-(2-hydroxy-phenyl)-2'-methylamino-3,4,5,6-tetrahydro-2H-[3,4']bipyridinyl-1-carboxylic acid tert-butyl ester 
• 406212-70-2 2'-acetylamino-3'-cyano-6'-(2-hydroxy-phenyl)-3,4,5,6-tetrahydro-2H-[3,4']bipyridinyl-1-carboxylic acid tert-butyl ester 
• 744216-11-3 2'-amino-3'-cyano-5'-fluoro-6'-(2-hydroxy-phenyl)-3,4,5,6-tetrahydro-2H-[3,4']bipyridinyl-1-carboxylic acid tert-butyl ester 
• 406212-53-1 tert-butyl 3-{2-amino-6-[2-(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate 
• 406212-60-0 tert-butyl 3-{2-bromo-6-[2-(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate 
• 744216-07-7 6'-(2-benzyloxy-phenyl)-3'-cyano-2'-methylamino-3,4,5,6-tetrahydro-2H-[3,4']bipyridinyl-1-carboxylic acid tert-butyl ester 
• 744216-10-2 2'-amino-6'-(2-benzyloxy-phenyl)-3'-cyano-5'-fluoro-3,4,5,6-tetrahydro-2H-[3,4']bipyridinyl-1-carboxylic acid tert-butyl ester 
• 406212-69-9 tert-butyl 3-{2-(acetylamino)-6-[2-(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate 
• 744216-08-8 6'-(2-benzyloxy-phenyl)-3'-cyano-2'-diacetylamino-3,4,5,6-tetrahydro-2H-[3,4']bipyridinyl-1-carboxylic acid tert-butyl ester 
• 639468-31-8 3-(4-fluorobenzoyl)piperidine-1-carboxylic acid tert-butyl ester 
• 858643-92-2 tert-butyl 3-acetylpiperidine-1-carboxylate 

Relevant academic research and scientific papers

Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B

The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological, and oncological disorders. This has promoted increased research into selective MAO-A and MAO-B inhibitors. Here, we shed light on how selective inhibition of MAO-A and MAO-B can be achieved by geometric isomers of cis-and trans-1-propargyl-4-styrylpiperidines. While the cis isomers are potent human MAO-A inhibitors, the trans analogues selectively target only the MAO-B isoform. The inhibition was studied by kinetic analysis, UV-vis spectrum measurements, and X-ray crystallography. The selective inhibition of the MAO-A and MAO-B isoforms was confirmed ex vivo in mouse brain homogenates, and additional in vivo studies in mice show the therapeutic potential of 1-propargyl-4-styrylpiperidines for central nervous system disorders. This study represents a unique case of stereoselective activity of cis/trans isomers that can discriminate between structurally related enzyme isoforms.

Aromatic cycloamines derivative and application in multi-target antidepressant medicine

The invention discloses an aromatic cycloamines derivative and an application in multi-target antidepressant medicine. The aromatic cycloamines derivative has inhibitory activity on 5-HT reuptake, NEreuptake and DA reuptake, is a novel compound of a 5-HT/

[1,2,4]-TRIAZOLO [1,5-A]-PYRIMIDINYL DERIVATIVES SUBSTITUTED WITH PIPERIDINE, MORPHOLINE OR PIPERAZINE AS OGA INHIBITORS

The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C90RF72 mutations.

ARYL-PIPERIDINE DERIVATIVES

An aryl-piperidine derivative of formula I, wherein the meaning of R3, X, Cz, and Cy is that specified in the description, for use as inhibitors of T cells.

(PIPERIDIN-3-YL)(NAPHTHALEN-2-YL)METHANONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HISTONE DEMETHYLASE KDM2B FOR THE TREATMENT OF CANCER

The present invention relates to (piperidin-3-yl)(naphthalen-2-yl) methanone derivatives and related compounds as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising

NOVEL COMPOUNDS THAT ARE ERK INHIBITORS

Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl ring, or a monocyclic heterocycloalkenyl ring, or a bridge

Identification of small-molecule inhibitors of Trypansoma cruzi replication

We report the outcome of a high-throughput small-molecule screen to identify novel, nontoxic, inhibitors of Trypansoma cruzi, as potential starting points for therapeutics to treat for both the acute and chronic stages of Chagas disease. Two compounds wer

NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS

Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.

SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

A series of substituted aryl sulfone derivatives represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more ot

Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs

Here we report the discovery and early SAR of a series of mGluR5 negative allosteric modulators (NAMs). Starting from a moderately active HTS hit we synthesized 3,5-disubstituted-oxadiazoles and tetrazoles as mGluR5 NAMs. Based on the analysis of ligand e