Technology Process of (22R,25R)-3β-O-tert-butyldiphenylsilyloxy-26-hydroxy-5-furosten
There total 2 articles about (22R,25R)-3β-O-tert-butyldiphenylsilyloxy-26-hydroxy-5-furosten which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride; aluminium trichloride;
In
diethyl ether;
at 20 ℃;
DOI:10.1002/ejoc.200300290
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 96 percent / imidazole / dimethylformamide
2: 47 percent / LiAlH4; AlCl3 / diethyl ether / 20 °C
With
1H-imidazole; lithium aluminium tetrahydride; aluminium trichloride;
In
diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200300290
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: Jones reagent / acetone / 3 h / 0 °C / Inert atmosphere
2.1: lithium bromide; trifluoroacetic anhydride / dichloromethane; acetonitrile / 24 h / 20 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen; sodium acetate / methanol; dichloromethane / 7 h / 30 °C / 7600.51 Torr
4.1: potassium carbonate / methanol / 3 h / 50 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
5.1: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere
6.1: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
7.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere
8.1: hydrogen / methanol / 4 h / 40 °C
9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 50 °C / Inert atmosphere
With
dmap; Jones reagent; sodium azide; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triethylamine; trifluoroacetic anhydride; lithium bromide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
1.1: |Jones Oxidation;
DOI:10.1021/acs.orglett.0c00747
