5-(3-{2-[4-(3-chloro-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid methyl ester

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Chemical Name:5-(3-{2-[4-(3-chloro-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid methyl ester
CAS No.:884490-80-6
Molecular Formula:C₂₃H₂₄ClNO₄S
Molecular Weight:445.967
Hs Code.:

Synonyms:5-(3-{2-[4-(3-chloro-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid methyl ester

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Chemical Property of 5-(3-{2-[4-(3-chloro-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid methyl ester

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Technology Process of 5-(3-{2-[4-(3-chloro-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid methyl ester

There total 9 articles about 5-(3-{2-[4-(3-chloro-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 346672-52-4
[3-(3-chloro-phenyl)-2-oxo-propyl]-phosphonic acid dimethyl ester

: 431989-54-7
(R)-methyl 5-(3-(2-formyl-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylate

: 884490-80-6
5-(3-{2-[4-(3-chloro-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid methyl ester

Guidance literature:: [3-(3-chloro-phenyl)-2-oxo-propyl]-phosphonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

(R)-methyl 5-(3-(2-formyl-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylate; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2012.02.018

Reference yield:

: 128899-30-9,100548-49-0,106191-02-0
(R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one

: 884490-80-6
5-(3-{2-[4-(3-chloro-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaHMDS / dimethylformamide / 0 °C

2.1: Et₃N; Pd(PPh₃)4; CuI / acetonitrile

3.1: H₂ / Pd/C

4.1: pyridinium trifluoroacetate; DMSO / benzene

4.2: NaH

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hexamethyldisilazane; pyridinium trifluroacetate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/j.bmcl.2006.01.018

Reference yield:

: 431990-31-7
(R)-5-(t-butyldimethylsiloxymethyl)-1-(2-propynyl)-2-pyrrolidinone

: 884490-80-6
5-(3-{2-[4-(3-chloro-phenyl)-3-oxo-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-propyl)-thiophene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N; Pd(PPh₃)4; CuI / acetonitrile

2.1: H₂ / Pd/C

3.1: pyridinium trifluoroacetate; DMSO / benzene

3.2: NaH

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; pyridinium trifluroacetate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In acetonitrile; benzene;
DOI:10.1016/j.bmcl.2006.01.018