tert-butyl (2-{[3-(2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)carbamate

Base Information

Chemical Name:tert-butyl (2-{[3-(2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)carbamate
CAS No.:1344738-22-2
Molecular Formula:C₂₄H₂₄N₄O₃S
Molecular Weight:448.546
Hs Code.:

Synonyms:tert-butyl (2-{[3-(2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)carbamate

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Chemical Property of tert-butyl (2-{[3-(2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)carbamate

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Technology Process of tert-butyl (2-{[3-(2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)carbamate

There total 9 articles about tert-butyl (2-{[3-(2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1344738-21-1
2-{6-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl tert-butyl carbonate

: 1344738-22-2
tert-butyl (2-{[3-(2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)carbamate

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; at 70 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm200677b

Reference yield:

: C₂₇H₂₃N₃O₄S₂

: 1344738-22-2
tert-butyl (2-{[3-(2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / methanol / 16 h / 20 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

4: sodium carbonate / 1,4-dioxane; water / 16 h / 70 °C / Inert atmosphere

With ammonia; boron tribromide; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b

Reference yield:

: 876299-48-8
2-(benzyloxy)benzaldehyde (5-bromopyridin-2-yl)hydrazone

: 1344738-22-2
tert-butyl (2-{[3-(2-hydroxyphenyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]thio}benzyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: [bis(acetoxy)iodo]benzene / ethanol; dichloromethane / 3 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

3: dichloromethane / 2 h / 20 °C / Inert atmosphere

4: ammonia / methanol / 16 h / 20 °C / Inert atmosphere

5: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

7: sodium carbonate / 1,4-dioxane; water / 16 h / 70 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [bis(acetoxy)iodo]benzene; ammonia; boron tribromide; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b