2-{6-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl tert-butyl carbonate

Base Information

Chemical Name:2-{6-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl tert-butyl carbonate
CAS No.:1344738-21-1
Molecular Formula:C₂₉H₃₂N₄O₅S
Molecular Weight:548.663
Hs Code.:

Synonyms:2-{6-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl tert-butyl carbonate

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Chemical Property of 2-{6-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl tert-butyl carbonate

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Technology Process of 2-{6-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl tert-butyl carbonate

There total 8 articles about 2-{6-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl tert-butyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 876300-13-9
2-(6-{[2-(aminomethyl)phenyl]thio}[1,2,4]triazolo[4,3-a]pyridin-3-yl)phenol

: 24424-99-5
di-tert-butyl dicarbonate

: 1344738-21-1
2-{6-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl tert-butyl carbonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1021/jm200677b

Reference yield:

: C₂₇H₂₃N₃O₄S₂

: 1344738-21-1
2-{6-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl tert-butyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / methanol / 16 h / 20 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

With ammonia; boron tribromide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b

Reference yield:

: 876299-48-8
2-(benzyloxy)benzaldehyde (5-bromopyridin-2-yl)hydrazone

: 1344738-21-1
2-{6-[(2-{[(tert-butoxycarbonyl)amino]methyl}phenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}phenyl tert-butyl carbonate

Guidance literature:: Multi-step reaction with 6 steps

1: [bis(acetoxy)iodo]benzene / ethanol; dichloromethane / 3 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

3: dichloromethane / 2 h / 20 °C / Inert atmosphere

4: ammonia / methanol / 16 h / 20 °C / Inert atmosphere

5: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; [bis(acetoxy)iodo]benzene; ammonia; boron tribromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b