4-piperidin-4-ylmethoxybenzaldehyde

Base Information

• Chemical Name: 4-piperidin-4-ylmethoxybenzaldehyde
• CAS No.: 1414975-23-7
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol file: 1414975-23-7.mol

Synonyms:4-piperidin-4-ylmethoxybenzaldehyde

Chemical Property of 4-piperidin-4-ylmethoxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-piperidin-4-ylmethoxybenzaldehyde

There total 4 articles about 4-piperidin-4-ylmethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(1-t-butoxycarbonylpiperidin-4-ylmethoxy)benzaldehyde (170726-00-8) → 4-piperidin-4-ylmethoxybenzaldehyde (1414975-23-7)

Guidance literature:

4-(1-t-butoxycarbonylpiperidin-4-ylmethoxy)benzaldehyde; With trifluoroacetic acid; In dichloromethane; at 22 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.1016/j.bmc.2012.09.024

Reference yield:

4-piperidinemethanol (6457-49-4) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-piperidin-4-ylmethoxybenzaldehyde (1414975-23-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2007.09.098

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-piperidin-4-ylmethoxybenzaldehyde (1414975-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 26 h / 0 - 22 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 22 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2012.09.024

upstream raw materials:

4-piperidinemethanol

4-hydroxy-benzaldehyde

tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

4-(1-t-butoxycarbonylpiperidin-4-ylmethoxy)benzaldehyde