(S)-1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl)phenyl)ethanamine

Base Information

Chemical Name:(S)-1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl)phenyl)ethanamine
CAS No.:1446021-23-3
Molecular Formula:C₂₁H₂₆N₂O
Molecular Weight:322.45
Hs Code.:

Synonyms:(S)-1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl)phenyl)ethanamine

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Chemical Property of (S)-1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl)phenyl)ethanamine

Chemical Property:

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Technology Process of (S)-1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl)phenyl)ethanamine

There total 3 articles about (S)-1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl)phenyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1446021-19-7
(S)-benzyl 1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl)phenyl)ethyl-carbamate

: 1446021-23-3
(S)-1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl)phenyl)ethanamine

Guidance literature:: With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol; at 20 ℃; under 1551.49 Torr;

Reference yield:

: 412004-56-9
4-bromo-1-(cyclopropylmethoxy)benzene

: 1446021-23-3
(S)-1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl)phenyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1: johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide / 1,4-dioxane / 45 °C

2: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 20 °C / 1551.49 Torr

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium hydroxide; johnphos; In 1,4-dioxane; ethanol;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1446021-23-3
(S)-1-(4-(1-(4-(cyclopropylmethoxy)phenyl)azetidin-3-yl)phenyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide / 1,4-dioxane / 45 °C

3: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 20 °C / 1551.49 Torr

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; potassium carbonate; sodium hydroxide; johnphos; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;