O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

Base Information

Chemical Name:O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide
CAS No.:1322510-91-7
Molecular Formula:C₂₇H₃₈N₇O₇P
Molecular Weight:603.615
Hs Code.:

Synonyms:O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

Suppliers and Price of O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

There total 3 articles about O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196833-56-3
N-α-(tert-butoxycarbonyl)-N-(isobutyl)-(L)-tyrosinamide

: 1322510-83-7
O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

: O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

: 1322510-91-7
O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

Guidance literature:: N-α-(tert-butoxycarbonyl)-N-(isobutyl)-(L)-tyrosinamide; O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide; In N,N-dimethyl-formamide; for 0.5h; Molecular sieve;

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; optical yield given as %de; Inert atmosphere; Molecular sieve;
DOI:10.1021/jm2001426

Reference yield:

: 1196833-56-3
N-α-(tert-butoxycarbonyl)-N-(isobutyl)-(L)-tyrosinamide

: 92999-29-6,92924-62-4,115226-05-6,121552-05-4
(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine

: O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

: 1322510-91-7
O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

Guidance literature:: (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Inert atmosphere;

N-α-(tert-butoxycarbonyl)-N-(isobutyl)-(L)-tyrosinamide; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 40 ℃; for 2h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jm2001426

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

: 1322510-91-7
O-[(5S)-5-[(6-amino-9H-purin-9-yl)methyl]-2-oxido-1,4,2-dioxaphosphinan-2-yl]-N-α-(tert-butoxycarbonyl)-N-(2-methylpropyl)-(L)-tyrosinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; triethylamine / dichloromethane / 0.25 h / 0 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere

2.2: 2 h / 40 °C / Inert atmosphere

With benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2001426