toluene-4-sulfonic acid (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentylmethyl ester

Base Information

Chemical Name:toluene-4-sulfonic acid (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentylmethyl ester
CAS No.:1418200-19-7
Molecular Formula:C₃₅H₄₄N₄O₆S₂Si
Molecular Weight:708.975
Hs Code.:

toluene-4-sulfonic acid (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentylmethyl ester

Synonyms:toluene-4-sulfonic acid (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentylmethyl ester

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Chemical Property of toluene-4-sulfonic acid (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentylmethyl ester

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Technology Process of toluene-4-sulfonic acid (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentylmethyl ester

There total 8 articles about toluene-4-sulfonic acid (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1418200-18-6
((1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentyl)-methanol

: 98-59-9
p-toluenesulfonyl chloride

: 1418200-19-7
toluene-4-sulfonic acid (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentylmethyl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;

Reference yield:

: 1418200-15-3
(1S,3R)-3-(5-amino-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentanecarboxylic acid methyl ester

: 1418200-19-7
toluene-4-sulfonic acid (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethyloxonium fluoroborate / tetrahydrofuran / 1 h / 20 °C

1.2: 3 h / 90 °C

2.1: 1H-imidazole / dichloromethane / 20 °C

3.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C

4.1: dmap / dichloromethane / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; triethyloxonium fluoroborate; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1418200-14-2
(1S,3R)-3-(1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentanecarboxylic acid methyl ester

: 1418200-19-7
toluene-4-sulfonic acid (1S,3R)-3-(6-benzenesulfonyl-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6H-1,3,5,6-tetraaza-as-indacen-1-yl)-cyclopentylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

2.1: triethyloxonium fluoroborate / tetrahydrofuran / 1 h / 20 °C

2.2: 3 h / 90 °C

3.1: 1H-imidazole / dichloromethane / 20 °C

4.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C

5.1: dmap / dichloromethane / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; In tetrahydrofuran; ethanol; dichloromethane;