5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Base Information

Chemical Name:5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS No.:310451-83-3
Molecular Formula:C₁₄H₇F₄N₃O₂
Molecular Weight:325.222
Hs Code.:
DSSTox Substance ID:DTXSID101133306
Mol file:310451-83-3.mol

Synonyms:5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid;310451-83-3;5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidine-3-carboxylic acid;DTXSID101133306;HMS1648E20;MFCD01194649;STK376854;AKOS000560795;CCG-202867;LS-03332;BB 0256563;EU-0060389;AB00099174-01;SR-01000596985;SR-01000596985-1

Suppliers and Price of 5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidine-3-carboxylic acid
500mg
$ 189.00

American Custom Chemicals Corporation
5-(4-FLUOROPHENYL)-7-(TRIFLUOROMETHYL)PYRAZOLO-[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID 95.00%
500MG
$ 785.40

Total 3 raw suppliers

Chemical Property of 5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:325.04743912
Heavy Atom Count:23
Complexity:454

Purity/Quality:

98%min ^*data from raw suppliers

5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidine-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C(=O)O)F

Technology Process of 5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

There total 4 articles about 5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 333761-24-3
5-(4-fluorophenyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

: 310451-83-3
5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Guidance literature:: 5-(4-fluorophenyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; With sodium hydroxide; In ethanol; water; at 65 ℃; for 4h;

With hydrogenchloride; at 20 ℃; pH=1;
DOI:10.5012/jkcs.2011.55.4.719

Reference yield:

: 582-65-0
1-(4-fluorophenyl)-4,4,4-trifluoro-1,3-butanedione

: 310451-83-3
5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 0.18 h / Microwave irradiation

2.1: sodium hydroxide / ethanol; water / 4 h / 65 °C

2.2: 20 °C / pH 1

With sodium hydroxide; In ethanol; water; acetic acid;
DOI:10.5012/jkcs.2011.55.4.719

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 310451-83-3
5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium / ethanol; toluene / 6 h / 60 °C

2: acetic acid / 7 h / 115 °C

3: sodium hydroxide; ethanol / 10 h / 65 °C

With ethanol; sodium; acetic acid; sodium hydroxide; In ethanol; toluene;