(S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid

Base Information

Chemical Name:(S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid
CAS No.:1201687-05-9
Molecular Formula:C₁₂H₁₁FN₂O₄
Molecular Weight:266.229
Hs Code.:

Synonyms:(S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid

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Chemical Property of (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid

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Technology Process of (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid

There total 7 articles about (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1201687-04-8
ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

: 1201687-05-9
(S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid

Guidance literature:: ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate; With water; triethylamine; lithium bromide; In acetonitrile; at 20 ℃;

With hydrogenchloride; In water; ethyl acetate; acetonitrile;

Reference yield: 49.0%

: 1201687-04-8
ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

: 1201687-05-9
(S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid

: 32222-45-0
(R)-2-(4-fluorophenyl)-2-hydroxyacetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; for 22h; Solvent; Inert atmosphere;
DOI:10.1021/op500134e

Reference yield:

: 32222-45-0
(R)-2-(4-fluorophenyl)-2-hydroxyacetic acid

: 1201687-05-9
(S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; dmap / dichloromethane / 20.5 h / 20 - 30 °C / Inert atmosphere

1.2: 1.42 h / 0 - 20 °C / Inert atmosphere

2.1: dichloromethane; hexane / 19.5 h / 20 - 22 °C / Inert atmosphere

2.2: 0.58 h / -30 - -13 °C / Inert atmosphere

2.3: 2.5 h / 20 °C / Inert atmosphere

3.1: cesium hydroxide; water / tetrahydrofuran / 22 h / Inert atmosphere

With pyridine; dmap; cesium hydroxide; water; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/op500134e