ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

Base Information

• Chemical Name: ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate
• CAS No.: 1201687-04-8
• Molecular Formula: C₁₄H₁₅FN₂O₄
• Molecular Weight: 294.283
• Mol file: 1201687-04-8.mol

Synonyms:ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

Chemical Property of ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

There total 5 articles about ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(R)-2-(4-fluorophenyl)-2-(trimethylsilyloxy)acetyl chloride (1201687-03-7) + ethyl acrylate (140-88-5,9003-32-1) + diazomethyl-trimethyl-silane (18107-18-1) → ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate (1201687-04-8)

Guidance literature:

ethyl acrylate; diazomethyl-trimethyl-silane; In hexanes; dichloromethane; at 20 ℃; for 20h; Inert atmosphere;

With trifluoroacetic acid; In hexanes; dichloromethane; at -30 ℃; for 0.583333h;

(R)-2-(4-fluorophenyl)-2-(trimethylsilyloxy)acetyl chloride;

Reference yield: 51.0%

(R)-2-(4-fluorophenyl)-2-(trimethylsilyloxy)acetyl chloride (1201687-03-7) + ethyl acrylate (140-88-5,9003-32-1) + diazomethyl-trimethyl-silane (18107-18-1) → ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate (1201687-04-8) + ethyl (R)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

Guidance literature:

ethyl acrylate; diazomethyl-trimethyl-silane; In hexane; dichloromethane; at 20 - 22 ℃; for 19.5h; Inert atmosphere;

With trifluoroacetic acid; In hexane; dichloromethane; at -30 - -13 ℃; for 0.583333h; Inert atmosphere;

(R)-2-(4-fluorophenyl)-2-(trimethylsilyloxy)acetyl chloride; In hexane; dichloromethane; at 20 ℃; for 2.5h; Temperature; Inert atmosphere;

DOI:10.1021/op500134e

Reference yield:

(R)-2-(4-fluorophenyl)-2-(trimethylsilyloxy)acetyl chloride (1201687-03-7) + C6H10N2O2 → ethyl (S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylate (1201687-04-8)

Guidance literature:

(R)-2-(4-fluorophenyl)-2-(trimethylsilyloxy)acetyl chloride; C₆H₁₀N₂O₂; With pyridine; In dichloromethane; at 20 ℃;

With methanol;

DOI:10.1039/c5md00479a

upstream raw materials:

(R)-2-(4-fluorophenyl)-2-(trimethylsilyloxy)acetyl chloride

ethyl acrylate

diazomethyl-trimethyl-silane

(R)-2-(4-fluorophenyl)-2-hydroxyacetic acid

Downstream raw materials:

(S)-1-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid

(5S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-1-[(2R)-2-(4-fluorophenyl)-2-hydroxyacetyl]-4,5-dihydro-1H-pyrazole-5-carboxamide

(R)-2-(4-fluorophenyl)-2-hydroxyacetic acid