1-{2-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-{2-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione
• CAS No.: 173776-19-7
• Molecular Formula: C₃₉H₅₀N₂O₇Si
• Molecular Weight: 686.921
• Mol file: 173776-19-7.mol

Synonyms:1-{2-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property of 1-{2-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{2-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

There total 11 articles about 1-{2-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-<2-deoxy-5-O-(tert-butyldimethylsilyl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane (173776-18-6) → 1-{2-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione (173776-19-7)

Guidance literature:

With dmap; In pyridine; at 25 ℃;

DOI:10.1016/0040-4039(95)01932-8

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 1-{2-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione (173776-19-7)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 1 h / 25 °C

2: DMAP / benzene / 25 °C

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; benzene;

DOI:10.1021/jo961548k

Reference yield:

1-(2-deoxy-α-D-erythro-pentofuranosyl)-2-(thymin-1-yl)ethane (173776-11-9) → 1-{2-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione (173776-19-7)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 1 h / 25 °C

2: DMAP / benzene / 25 °C

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; benzene;

DOI:10.1021/jo961548k

upstream raw materials:

4,4'-dimethoxytrityl chloride

1-<2-deoxy-5-O-(tert-butyldimethylsilyl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane

tert-butyldimethylsilyl chloride

1-(2-deoxy-α-D-erythro-pentofuranosyl)-2-(thymin-1-yl)ethane

Downstream raw materials:

1-<2-deoxy-3-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane