2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide

Base Information

Chemical Name:2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
CAS No.:1352936-87-8
Molecular Formula:C₂₇H₂₄ClN₅O
Molecular Weight:469.973
Hs Code.:

Synonyms:2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide

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Chemical Property of 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide

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Technology Process of 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide

There total 12 articles about 2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1352936-87-8
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide

Guidance literature:: With palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; anhydrous sodium carbonate; In 1,4-dioxane; at 140 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1352937-69-9
[(4S)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

: 557-66-4
ethanamine hydrochloride

: 1352936-87-8
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 1352936-87-8
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 3.5 h / Reflux

2.1: toluene; diethyl ether / 1 h / 0 - 20 °C

3.1: chloroform / 1 h / 60 °C

4.1: triethylamine / dichloromethane / 24 h / Reflux

4.2: 2 h / 60 °C

5.1: sodium carbonate; phosphorus pentoxide / 1,2-dichloro-ethane / 2 h / 70 °C

6.1: hydrazine hydrate / tetrahydrofuran / 5 h / 0 - 15 °C

6.2: 16 h / 0 - 20 °C

7.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 20 °C

9.1: boron tribromide / dichloromethane / 0.42 h / -78 - 20 °C / Reflux

9.2: 3.5 h / Reflux

10.1: pyridine / dichloromethane / 2.5 h / Cooling an ice bath

11.1: sodium hydroxide; sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1.5 h / 120 °C / Microwave irradiation

12.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With pyridine; phosphorus pentoxide; water; boron tribromide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; chloroform; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;