3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-phenethyl-pyran-2-one

Base Information

Chemical Name:3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-phenethyl-pyran-2-one
CAS No.:176771-66-7
Molecular Formula:C₂₃H₂₃NO₃
Molecular Weight:361.441
Hs Code.:

Synonyms:3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-phenethyl-pyran-2-one

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Chemical Property of 3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-phenethyl-pyran-2-one

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Technology Process of 3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-phenethyl-pyran-2-one

There total 3 articles about 3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-phenethyl-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {3-[Cyclopropyl-(4-hydroxy-2-oxo-6-phenethyl-2H-pyran-3-yl)-methyl]-phenyl}-carbamic acid benzyl ester

: 176771-66-7
3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-phenethyl-pyran-2-one

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol;
DOI:10.1021/jm950888f

Reference yield:

: 162174-77-8
m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol

: 176771-66-7
3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-phenethyl-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / TsOH*H₂O, 3 A molecular sieves / CH₂Cl₂ / 6 h / Heating

2: 1.) LDA*THF / 1.) THF, cyclohexane, from -78 deg C to -20 deg C, 2.) THF, cyclohexane, from -78 deg C to -20 deg C

3: HCO₂NH₄ / 5percent Pd/C / methanol

With 3 A molecular sieve; ammonium formate; toluene-4-sulfonic acid; lithium diisopropyl amide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm950888f

Reference yield:

: 174485-05-3
3-(α-Cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-4-hydroxy-6-methyl-pyran-2-one

: 176771-66-7
3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-phenethyl-pyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA*THF / 1.) THF, cyclohexane, from -78 deg C to -20 deg C, 2.) THF, cyclohexane, from -78 deg C to -20 deg C

2: HCO₂NH₄ / 5percent Pd/C / methanol

With ammonium formate; lithium diisopropyl amide; palladium on activated charcoal; In methanol;
DOI:10.1021/jm950888f