174485-05-3

Upstream product

• 675-10-5 4-hydroxy-6-methyl-2-pyron 
• 162174-77-8 m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol 

Downstream Products

• 174485-06-4 3-(α-Cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-4-hydroxy-6-propyl-pyran-2-one 
• 162174-72-3 3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one 
• 162170-49-2 3-(α-cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-(α-ethyl-phenethyl)-4-hydroxy-2H-pyran-2-one 
• 176771-66-7 3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-phenethyl-pyran-2-one 
• 174485-04-2 3-(α-Cyclopropyl-meta-aminobenzyl)-4-hydroxy-6-[3-(2-methoxy-ethoxy)-propyl]-pyran-2-one 
• 174485-19-9 3-[(3-Amino-phenyl)-cyclopropyl-methyl]-4-hydroxy-6-[1-(tetrahydro-pyran-4-ylmethyl)-propyl]-pyran-2-one 
• 174485-08-6 3-(α-Cyclopropyl-meta-aminobenzyl)-6-[1-ethyl-3-(2-methoxy-ethoxy)-propyl]-4-hydroxy-pyran-2-one 
• 174485-18-8 [3-(Cyclopropyl-{4-hydroxy-2-oxo-6-[1-(tetrahydro-pyran-4-ylmethyl)-propyl]-2H-pyran-3-yl}-methyl)-phenyl]-carbamic acid benzyl ester 
• 162169-82-6 3-(α-cyclopropyl-meta-(4-cyanophenylsulfonylamino)benzyl)-6-(α-ethylphenethyl)-4-hydroxy-2H-pyran-2-one 
• 174485-07-5 3-(α-Cyclopropyl-meta-(benzyloxycarbonylamino)benzyl)-6-[1-ethyl-3-(2-methoxy-ethoxy)-propyl]-4-hydroxy-pyran-2-one 

Relevant academic research and scientific papers

Structure-based design of novel HIV protease inhibitors: Sulfonamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent non-peptidic inhibitors

The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents. Our broad screening program to discover non-peptidic HIV protease inhibitors previously identif

PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS

The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R 10 and R 20 taken together are formulae (III) and (IV). STR1