N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

Base Information

Chemical Name:N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide
CAS No.:1352213-67-2
Molecular Formula:C₂₆H₂₃NO₃S
Molecular Weight:429.54
Hs Code.:

Synonyms:N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

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Chemical Property of N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

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Technology Process of N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

There total 7 articles about N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 696-62-8
para-iodoanisole

: 170751-31-2
4-methyl-N-(3-phenylprop-2-yn-1-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide

: 1352213-67-2
N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

Guidance literature:: para-iodoanisole; 4-methyl-N-(3-phenylprop-2-yn-1-yl)-N-(prop-2-yn-1-yl)benzenesulfonamide; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

With DBN; In tetrahydrofuran; at 60 ℃; for 8h; Schlenk technique; Inert atmosphere;
DOI:10.1021/jo301437k

Reference yield: 69.0%

: 173019-85-7
3-bromo-1-(4-methoxyphenyl)propyne

: 305837-95-0
4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

: 1352213-67-2
N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;
DOI:10.1021/jo402749d

Reference yield:

: 591-50-4
iodobenzene

: 1352213-67-2
N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 3 h / 30 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/jo402749d