2-(1-(4-(2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yloxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Base Information

Chemical Name:2-(1-(4-(2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yloxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile
CAS No.:1610369-84-0
Molecular Formula:C₂₈H₂₃FN₄O₃
Molecular Weight:482.514
Hs Code.:

Synonyms:2-(1-(4-(2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yloxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Chemical Property of 2-(1-(4-(2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yloxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Technology Process of 2-(1-(4-(2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yloxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

There total 6 articles about 2-(1-(4-(2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yloxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1610369-83-9
2-(1-(4-(4-bromo-2-methylphenoxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

: 406482-19-7
2-fluoro-5-methoxyphenylboronic acid

: 1610369-84-0
2-(1-(4-(2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yloxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

Reference yield:

: 1610369-78-2
5-(cyanomethyl)-N-(2,2-dimethoxyethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

: 1610369-84-0
2-(1-(4-(2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yloxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; water / tetrahydrofuran / 60 h / 20 °C

2: triethylamine; triphenylphosphine / acetonitrile / 0 - 20 °C

3: boron dimethyl-trifluoro sulphide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; 1,4-dioxane / 90 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron dimethyl-trifluoro sulphide; water; oxygen; copper diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

: 1610369-80-6
5-(cyanomethyl)-1-(4-methoxyphenyl)-N-(2-oxoethyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

: 1610369-84-0
2-(1-(4-(2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yloxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; triphenylphosphine / acetonitrile / 0 - 20 °C

2: boron dimethyl-trifluoro sulphide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; 1,4-dioxane / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron dimethyl-trifluoro sulphide; oxygen; copper diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; acetonitrile;