2-(1-(4-(4-bromo-2-methylphenoxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Base Information

Chemical Name:2-(1-(4-(4-bromo-2-methylphenoxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile
CAS No.:1610369-83-9
Molecular Formula:C₂₁H₁₇BrN₄O₂
Molecular Weight:437.296
Hs Code.:

Synonyms:2-(1-(4-(4-bromo-2-methylphenoxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Chemical Property of 2-(1-(4-(4-bromo-2-methylphenoxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Technology Process of 2-(1-(4-(4-bromo-2-methylphenoxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

There total 5 articles about 2-(1-(4-(4-bromo-2-methylphenoxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 221006-71-9
(4-bromo-2-methylphenyl)boronic acid

: 1610369-82-8
2-(1-(4-hydroxyphenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

: 1610369-83-9
2-(1-(4-(4-bromo-2-methylphenoxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: With oxygen; copper diacetate; triethylamine; In dichloromethane; Molecular sieve;

Reference yield:

: 1610369-78-2
5-(cyanomethyl)-N-(2,2-dimethoxyethyl)-1-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

: 1610369-83-9
2-(1-(4-(4-bromo-2-methylphenoxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / tetrahydrofuran / 60 h / 20 °C

2: triethylamine; triphenylphosphine / acetonitrile / 0 - 20 °C

3: boron dimethyl-trifluoro sulphide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

With hydrogenchloride; boron dimethyl-trifluoro sulphide; water; oxygen; copper diacetate; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 1610369-80-6
5-(cyanomethyl)-1-(4-methoxyphenyl)-N-(2-oxoethyl)-4,5-dihydro-1H-pyrazole-3-carboxamide

: 1610369-83-9
2-(1-(4-(4-bromo-2-methylphenoxy)phenyl)-3-(oxazol-2-yl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; triphenylphosphine / acetonitrile / 0 - 20 °C

2: boron dimethyl-trifluoro sulphide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: triethylamine; copper diacetate; oxygen / dichloromethane / Molecular sieve

With boron dimethyl-trifluoro sulphide; oxygen; copper diacetate; triethylamine; triphenylphosphine; In dichloromethane; acetonitrile;