2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-(4-chlorophenyl)ethanone

Base Information

Chemical Name:2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-(4-chlorophenyl)ethanone
CAS No.:1286278-57-6
Molecular Formula:C₂₂H₁₇ClN₈O
Molecular Weight:444.883
Hs Code.:

Synonyms:2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-(4-chlorophenyl)ethanone

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Chemical Property of 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-(4-chlorophenyl)ethanone

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Technology Process of 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-(4-chlorophenyl)ethanone

There total 6 articles about 2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-(4-chlorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1286278-45-2
C₁₄H₁₁N₅

: 26086-60-2
2-azido-4'-chloroacetophenone

: 1286278-57-6
2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-(4-chlorophenyl)ethanone

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In dimethyl sulfoxide; acetonitrile; at 20 ℃; for 3h; regioselective reaction;
DOI:10.1016/j.bmcl.2011.01.047

Reference yield:

: 42754-56-3
2-(methoxyphenylmethylene)malononitrile

: 1286278-57-6
2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-(4-chlorophenyl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrochloride; triethylamine

2: 24 h / 180 °C

3: sodium carbonate / acetone; toluene / 24 h / 20 °C

4: copper(II) sulfate; sodium L-ascorbate / dimethyl sulfoxide; acetonitrile / 3 h / 20 °C

With hydrazine hydrochloride; sodium carbonate; copper(II) sulfate; sodium L-ascorbate; triethylamine; In dimethyl sulfoxide; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.047

Reference yield:

: 5515-36-6
α-cyano-β-hydroxycinnamonitrile

: 1286278-57-6
2-(4-((4-amino-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-(4-chlorophenyl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / 1,4-dioxane

2: hydrazine hydrochloride; triethylamine

3: 24 h / 180 °C

4: sodium carbonate / acetone; toluene / 24 h / 20 °C

5: copper(II) sulfate; sodium L-ascorbate / dimethyl sulfoxide; acetonitrile / 3 h / 20 °C

With hydrazine hydrochloride; sodium hydrogencarbonate; sodium carbonate; copper(II) sulfate; sodium L-ascorbate; triethylamine; In 1,4-dioxane; dimethyl sulfoxide; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.047